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Title:	Serious drug-induced liver disease secondary to ezetimibe
Author:	Castellote Alonso, José; Ariza Cardenal, Javier; Rota, Rosa; Girbau, Anna; Xiol Quingles, Xavier
Abstract:	Ezetimibe is the first member of a new family of lipid-lowering drugs that inhibits uptake of dietary and biliary cholesterol. It was approved by the FDA in 2002 for hypercholesterolemia alone or in combination with statins. Its use has been spreading over the last years. Ezetimibe was considered a safe drug. We report a case of a woman who developed a serious hepatocellular drug-induced liver disease after 4 mo therapy with 10 mg daily of ezetimibe. After withdrawal of the drug, the patient recovered slowly. Ezetimibe may produce serious toxic hepatitis and prompt withdrawal is mandatory in case of a significant abnormality in liver testing after beginning or during treatment with ezetimibe.
Subject(s):	-Hepatitis -Efectes secundaris dels medicaments -Malalties del fetge -Hepatitis -Drug side effects -Liver diseases
Rights:	cc-by-nc (c) Castellote Alonso, José et al., 2008 http://creativecommons.org/licenses/by-nc/3.0/es
Document type:	Article Article - Published version
Published by:	Baishideng Publishing Group
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