Title:
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Simultaneous cyclization and derivatization of peptides using cyclopentenediones
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Author:
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Brun Cubero, Omar; Archibald, L. J.; Agramunt, Jordi; Pedroso Muller, Enrique; Grandas Segarra, Anna
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Other authors:
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Universitat de Barcelona |
Abstract:
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Unprotected linear peptides containing N-terminal cysteines and another cysteine residue can be simultaneously cyclized and derivatized using 2,2-disubstituted cyclopentenediones. High yields of cyclic peptide conjugates may be obtained in short reaction times using only a slight excess of the cyclopentenedione moiety under TEMPO catalysis and in the presence of LiCl. |
Subject(s):
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-Pèptids -Cisteïna -Estructura molecular -Peptides -Cysteine -Molecular structure |
Rights:
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(c) American Chemical Society , 2017
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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