An array of mooring lines deployed between 300 and 1900 m depth along the Lacaze-Duthiers and Cap de Creus canyons and in the adjacent southern open slope was used to study the water and sediment transport on the western Gulf of Lions margin during the 2006 intense cascading period. Deep-reaching cascading pulses occurred in early January, in late January and from early March to mid-April. Dense water and sediment transport to the deep environments occurred not only through submarine canyons, but also along the southern open slope. During the deep cascading pulses, temporary upper and mid-canyon and open slope deposits were an important source of sediment to the deep margin. Significant sediment transport events at the canyon head only occurred in early January because of higher sediment availability on the shelf after the stratified and calm season, and in late February because of the interaction of dense shelf water cascading with a strong E-SE storm. During the January deep cascading pulses, increases in suspended sediment concentration within the canyon were greater and earlier at 1000 m depth than at 300 m depth, whereas during the March-April deep cascading pulses sediment concentration only increased below 300 m depth, indicating resuspension and redistribution of sediments previously deposited at upper and mid-canyon depths. Deeper than 1000 m depth, net fluxes show that most of the suspended sediment left the canyon and flowed along the southern open slope towards the Catalan margin, whereas a small part flowed down-canyon and was exported basinward. Additionally, on the mid- and lower-continental slope there was an increase in the near-bottom currents induced by deep open-sea convection processes and the propagation of eddies. This, combined with the arrival of deep cascading pulses, also generated moderate suspended sediment transport events in the deeper slope regions.