Título:
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Hybrid polypeptide/polylactide copolymers with short phenylalanine blocks
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Autor/a:
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Mayans Tayadella, Enric; Murase Fernández, Sara Keiko; Pérez Madrigal, Maria del Mar; Cativiela, Carlos; Alemán Llansó, Carlos; Puiggalí Bellalta, Jordi
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Otros autores:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies; Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables. |
Abstract:
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This is the peer reviewed version of the following article: Mayans, E., et al. Hybrid polypeptide/polylactide copolymers with short phenylalanine blocks. "Macromolecular chemistry and physics", 29 Juliol 2018, vol. 219, núm. 17, p. 1800168-1-1800168-11, which has been published in final form at https://doi.org/10.1002/macp.201800168. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Abstract:
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Hybrid copolymers constituted by short l-phenylalanine (Phe) blocks (i.e., Phen with n ranging from 2 to 25) and l-lactide blocks of different length are synthesized and characterized. The diblock structure is obtained by ring opening polymerization of lactide using a Phe-oligopeptide as macroinitiator. The length of the poly(l-lactide) (PLLA) block is controlled through the [lactide]/[macroinitiator] ratio. Morphologic studies of such hybrid copolymers indicate that the assembly of PLLA can be controlled by introducing short Phe blocks. Spherulites with both positive and negative birefringence are achieved in melt crystallization as a consequence of different lamellar distributions. Instead, a high variety of structures are detected in solution-crystallized samples. Specifically, lozenge single crystals, flower-like crystals, fibrillar structures, compact spheres, ringed sperulites, dendritic structures, microfibers, and braid-like microstructures are observed. Some of the detected morphologies are characteristic of self-assembled Phe-oligopeptides, suggesting that Phe-blocks play a crucial role in the self-assembly properties. |
Abstract:
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Peer Reviewed |
Materia(s):
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-Àrees temàtiques de la UPC::Enginyeria química -Polymers--Biodegradation -Ring-opening polymerization -Polylactic acid -Phenylalanine -Crystalline morphologies -Hybrid copolymers -Polylactide -Polyphenylalanine -Ring-opening polymerization -Self-assembling -Polímers -- Biodegradació |
Derechos:
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Tipo de documento:
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Artículo - Versión presentada Artículo |
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