Título:
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Asymmetric Synthesis of -Disubstituted Allylic Amines via Pd- Catalyzed Allylic Substitution
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Autor/a:
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Guo, Wusheng; Cai, Aijie; Xie, Jianing; Kleij, Arjan W.
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Abstract:
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The first asymmetric synthesis of important - disubstituted N-alkyl allyl amine scaffolds via allylic substitution is reported. This approach is based on palladium catalysis and features ample scope in both allylic precursor and amine reagent, and high asymmetric induction with the enantiomeric ratio (er) up to 98.5:1.5. The use of less reactive anilines is also feasible providing enantioenriched -disubstituted N-aryl allylic amines. |
Fecha de creación:
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18-09-2017 |
Materia(s):
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54 |
Derechos:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Páginas:
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11797 p. |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
DOI:
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10.1002/anie.201705825
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Compartir:
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