This article shows the methodology and the main figures of the local and regional economic impact generated by cruise activity. This article is pioneering in combining different issues: estimating the impact of the cruise port activity, presenting these impacts disaggregated at a sectoral level, using a rigorous methodology and carrying out extensive fieldwork. It is demonstrated that all sectors, not just traditional tourism-related sectors, benefit from cruise tourism. In order to test and apply our methodology we focus the analysis on the Port of Barcelona, which has become the leading cruise port in the Mediterranean area.