Título:
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BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
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Autor/a:
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Welz, Patrick-Simon; Zinna, Valentina M.; Symeonidi, Aikaterini; Koronowski, Kevin B.; Kinouchi, Kenichiro; Smith, Jacob G.; Marín Guillén, Inés; Castellanos, Andrés; Furrow, Stephen; Aragón, Ferrán; Crainiciuc, Georgiana; Prats, Neus; Martín Caballero, Juan; Hidalgo, Andrés; Sassone-Corsi, Paolo; Aznar Benitah, Salvador
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Abstract:
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Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues. |
Materia(s):
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-Ritmes circadiaris -Fisiologia -Circadian rhythms -Physiology |
Derechos:
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cc by-nc-nd (c) Welz et al., 2019
info:eu-repo/semantics/embargoedAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Elsevier
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Compartir:
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