Títol:
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[60]Fullerene for medicinal purposes, a purity criterion towards regulatory considerations
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Autor/a:
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Keykhosravi, Sanaz; Rietveld, Ivo B.; Couto, Diana; Tamarit Mur, José Luis; Barrio Casado, María del; Céolin, René; Moussa, Fathi
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Altres autors:
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Universitat Politècnica de Catalunya. Departament de Física; Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials |
Abstract:
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Since the early nineties countless publications have reported promising medicinal applications for [60]fullerene (C60) related to its unparalleled affinity towards free radicals. Yet, until now no officially approved C60-based drug has reached the market, notably because of the alleged dangers of C60. Nevertheless, since the publication of the effects of C60 on the lifespan of rodents, a myriad of companies started selling C60 worldwide for human consumption without any approved clinical trial. Nowadays, several independent teams have confirmed the safety of pure C60 while demonstrating that previously observed toxicity was due to impurities present in the used samples. However, a purity criterion for C60 samples is still lacking and there are no regulatory recommendations on this subject. In order to avoid a public health issue and for regulatory considerations, a quality-testing strategy is urgently needed. Here we have evaluated several analytical tools to verify the purity of commercially available C60 samples. Our data clearly show that differential scanning calorimetry is the best candidate to establish a purity criterion based on the sc-fcc transition of a C60 sample (Tonset 258 K, Dsc-fccH 8 J g¿1). |
Abstract:
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Peer Reviewed |
Matèries:
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-Àrees temàtiques de la UPC::Enginyeria dels materials -Nanostructured materials -Nanomedicine -Fullerene -C60 -Purity -Differential scanning calorimetry (DSC) -Gas chromatography mass -Spectrometry (GC-MS) -Nanomaterials -Nanomedicine -Materials nanoestructurats -Nanomedicina |
Drets:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipus de document:
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Article - Versió publicada Article |
Publicat per:
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Multidisciplinary Digital Publishing Institute (MDPI)
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