COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

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Título:	COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
Autor/a:	Tomlinson, Ian P.; Dunlop, Malcolm; Campbell, Harry; Zanke, Brent; Gallinger, Steven; Hudson, Thomas J.; Koessler, Thibaud; Pharoah, Paul D. P.; Niittymäki, Iina; Tuupanen, Sari; Aaltonen, Lauri A.; Hemminki, Kari; Lindblom, Annika; Försti, Asta; Sieber, Oliver; Lipton, Lara; Van Wezel, Tom; Morreau, Hans; Wijnen, Juul; Devilee, Peter; Matsuda, Kenji; Nakamura, Yusuke; Castellví-Bel, Sergi; Ruiz-Ponte, Clara; Castells Garangou, Antoni; Carracedo Álvarez, Ángel; Ho, J.W.; Sham, Pak Chung; Hofstra, Robert; Vodicka, Pavel; Brenner, Hermann; Hampe, Jochen; Schafmayer, Clemens; Tepel, Juergen; Schreiber, Stefan; Völzke, Henry; Lerch, Markus M.; Schmidt, Christian A.; Buch, Stephan; Moreno Aguado, Víctor
Abstract:	It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
Materia(s):	-Càncer colorectal -Genètica -Polimorfisme genètic -Colorectal cancer -Genetics -Genetic polymorphisms
Derechos:	(c) Tomlinson, Ian P. et al., 2010
Tipo de documento:	Artículo Artículo - Versión aceptada
Editor:	Cancer Research UK
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COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

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