Title:
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Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes under Visible-Light Photoredox Catalysis
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Author:
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Claros, Miguel; Ungeheuer, Felix; Franco, Federico; Martin-Diaconescu, Vlad; Casitas, Alicia; Lloret-Fillol, Julio
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Abstract:
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The chemical inertness of abundant and commercially
available alkyl chlorides precludes their widespread use
as reactants in chemical transformations. Presented in this
work is a metallaphotoredox methodology to achieve the
catalytic intramolecular reductive cyclization of unactivated
alkyl chlorides with tethered alkenes. The cleavage of strong
C(sp3)@Cl bonds is mediated by a highly nucleophilic lowvalent
cobalt or nickel intermediate generated by visible-light
photoredox reduction employing a copper photosensitizer. The
high basicity and multidentate nature of the ligands are key to
obtaining efficient metal catalysts for the functionalization of
unactivated alkyl chlorides. |
Publication date:
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2019-02-01 |
Subject(s):
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54 |
Rights:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Pages:
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4869 p. |
Document type:
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Article Article - Accepted version |
DOI:
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10.1002/anie.201812702
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