RECERCAT Principal
>
Universitat Autònoma de Barcelona
>
Articles escrits per personal UAB o publicats per la universitat
>
Visualizar documento
| Título: | Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma |
|---|---|
| Autor/a: | Lavarino, Cinzia; Cheung, Nai-Kong V.; García, Idoia; Domènech Gómez, Gemma; Torres, Carmen de; Alaminos, Miguel; Ríos Guillermo, José; Gerald, William L.; Kushner, Brian; LaQuaglia, Mike; Mora, Jaume |
| Abstract: | Background: Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficult, but critical for therapeutic decisions. The aim of this study was to investigate chromosomal alterations and differential gene expression amongst infant disseminated NB subgroups. Methods: Thirty-five NB tumours from patients diagnosed at < 18 months (25 stage 4 and 10 stage 4s), were evaluated by allelic and gene expression analyses. Results: All stage 4s patients underwent spontaneous remission, only 48% stage 4 patients survived despite combined modality therapy. Stage 4 tumours were 90% near-diploid/tetraploid, 44% MYCN amplified, 77% had 1p LOH (50% 1p36), 23% 11q and/or 14q LOH (27%) and 47% had 17q gain. Stage 4s were 90% near-triploid, none MYCN amplified and LOH was restricted to 11q. Initial comparison analyses between stage 4s and 4 < 12 months tumours revealed distinct gene expression profiles. A significant portion of genes mapped to chromosome 1 (P < 0.0001), 90% with higher expression in stage 4s, and chromosome 11 (P = 0.0054), 91% with higher expression in stage 4. Less definite expression profiles were observed between stage 4s and 4 < 18m, yet, association with chromosomes 1 (P < 0.0001) and 11 (P = 0.005) was maintained. Distinct gene expression profiles but no significant association with specific chromosomal region localization was observed between stage 4s and stage 4 < 18 months without MYCN amplification. Conclusion: Specific chromosomal aberrations are associated with distinct gene expression profiles which characterize spontaneously regressing or aggressive infant NB, providing the biological basis for the distinct clinical behaviour. |
| Fecha de creación: | 09-09-2021 |
| Derechos: | open access
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/3.0/ |
| Tipo de documento: | Article |
| Editor: | |
| Compartir: |
|
| Uri: | https://ddd.uab.cat/record/113554 |
Documentos relacionados
Otros documentos del mismo autor/a
Hernández-Muñoz, Inmaculada; Figuerola, Elisabeth; Sanchez-Molina, Sara; Rodriguez García, Eva; Fernández Mariño, Ana Isabel, 1984-; Pardo-Pastor, Carlos; Bahamonde Santos, María Isabel, 1972-; Fernández-Fernández, José Manuel, 1967-; García-Domínguez, Daniel J.; Hontecillas-Prieto, Lourdes; Lavarino, Cinzia; Carcaboso, Angel M.; Torres, Carmen de; Tirado, Oscar M.; Alava, Enrique de; Mora, Jaume
Berdasco, María; Gómez, Antonio; Rubio, Marcos J.; Català Mora, Jaume; Zanón Moreno, Vicente; Lopez, Miguel; Hernandez, Cristina; Yoshida, Shigeo; Nakama, Takahito; Ishikawa, Keijiro; Ishibashi, Tatsuro; Boubekeur, Amina M.; Louhibi, Lotfi; Pujana Genestar, M. Ángel; Sayols, Sergi; Setien, Fernando; Corella, Dolores; Torres, Carmen de; Parareda, Andreu; Mora, Jaume; Zhao, Ling; Zhang, Kang; Lleonart, Matilde E.; Alonso, Javier; Simó, Rafael; Caminal Mitjana, Josep Maria; Esteller, Manel
Berdasco, María; Gómez, Antonio; Rubio, Marcos J.; Català Mora, Jaume; Zanón Moreno, Vicente; Lopez, Miguel; Hernandez, Cristina; Yoshida, Shigeo; Nakama, Takahito; Ishikawa, Keijiro; Ishibashi, Tatsuro; Boubekeur, Amina M.; Louhibi, Lotfi; Pujana Genestar, M. Ángel; Sayols, Sergi; Setien, Fernando; Corella, Dolores; Torres, Carmen de; Parareda, Andreu; Mora, Jaume; Zhao, Ling; Zhang, Kang; Lleonart, Matilde E.; Alonso, Javier; Simó, Rafael; Caminal Mitjana, Josep Maria; Esteller, Manel
Krauel, Lucas; Fenollosa i Artés, Felip; Riaza, Lucía; Pérez, Martín; Tarrado, Xavier; Morales, Andrés; Gomà Ayats, Joan Ramon; Mora, Jaume
Mayol, Gemma; Martín-Subero, José Ignacio; Ríos, José; Queirós, Ana C.; Kulis, Marta; Suñol, Mariona; Esteller, Manel; Gómez, Soledad; Garcia, Idoia; de Torres, Carmen; Rodríguez, Eva; Galván, Patricia; Mora Graupera, Jaume; Lavarino, Cinzia