dc.contributor.author |
De Niz, Mariana |
dc.contributor.author |
Ullrich, Ann-Katrin |
dc.contributor.author |
Heiber, Arlett |
dc.contributor.author |
Blancke Soares, Alexandra |
dc.contributor.author |
Pick, Christian |
dc.contributor.author |
Lyck, Ruth |
dc.contributor.author |
Keller, Derya |
dc.contributor.author |
Kaiser, Gesine |
dc.contributor.author |
Prado, Monica |
dc.contributor.author |
Flemming, Sven |
dc.contributor.author |
Portillo Obando, Hernando A. del |
dc.contributor.author |
Janse, Chris J. |
dc.contributor.author |
Heussler, Volker T. |
dc.contributor.author |
Spielmann, Tobias |
dc.date |
2016 |
dc.identifier |
https://ddd.uab.cat/record/174663 |
dc.identifier |
urn:10.1038/ncomms11659 |
dc.identifier |
urn:oai:ddd.uab.cat:174663 |
dc.identifier |
urn:pmid:27225796 |
dc.identifier |
urn:articleid:20411723v7p11659 |
dc.identifier |
urn:scopus_id:84971207227 |
dc.identifier |
urn:wos_id:000376668400001 |
dc.identifier |
urn:altmetric_id:8284849 |
dc.identifier |
urn:pmc-uid:4894950 |
dc.identifier |
urn:pmcid:PMC4894950 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:4894950 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
European Commission 242095 |
dc.relation |
Nature communications ; Vol. 7 (May 2016), article 11659 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Citologia |
dc.subject |
Malària |
dc.subject |
Parasitologia |
dc.subject |
Cell biology |
dc.subject |
Malaria |
dc.subject |
Pârasitology |
dc.title |
The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: Swiss National Foundation (grant 10030_140691/1), Deutsche Forschungsgemeinschaft (SP 1209/1) |
dc.description.abstract |
Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 and MAHRP1. Red blood cells infected with P. berghei parasites lacking SBP1 or MAHRP1a fail to bind the endothelial receptor CD36 and show reduced sequestration and virulence in mice. Complementation of the mutant P. berghei parasites with the respective P. falciparum SBP1 and MAHRP1 orthologues restores sequestration and virulence. These findings reveal evolutionary conservation of the machinery underlying sequestration of divergent malaria parasites and support the notion that the P. berghei rodent model is an adequate tool for research on malaria virulence. |