dc.contributor.author |
Font Inglès, Joan |
dc.contributor.author |
López-Cano, Marc |
dc.contributor.author |
Notartomaso, Serena |
dc.contributor.author |
Scarselli, Pamela |
dc.contributor.author |
Di Pietro, Paola |
dc.contributor.author |
Bresolí-Obach, Roger |
dc.contributor.author |
Battaglia, Giuseppe |
dc.contributor.author |
Malhaire, Fanny |
dc.contributor.author |
Rovira, Xavier |
dc.contributor.author |
Catena, Juanlo |
dc.contributor.author |
Giraldo, Jesús |
dc.contributor.author |
Pin, Jean-Philippe |
dc.contributor.author |
Fernández-Dueñas, Víctor |
dc.contributor.author |
Goudet, Cyril |
dc.contributor.author |
Nonell, Santi |
dc.contributor.author |
Nicoletti, Ferdinando |
dc.contributor.author |
Llebaria, Amadeu |
dc.contributor.author |
Ciruela, Francisco |
dc.date |
2017 |
dc.identifier |
https://ddd.uab.cat/record/186204 |
dc.identifier |
urn:10.7554/eLife.23545 |
dc.identifier |
urn:oai:ddd.uab.cat:186204 |
dc.identifier |
urn:pmid:28395733 |
dc.identifier |
urn:pmcid:PMC5388536 |
dc.identifier |
urn:pmc-uid:5388536 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/4a46d460-f871-4b89-a7d4-65fa57d6de22 |
dc.identifier |
urn:scopus_id:85017446262 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:5388536 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Economía y Competitividad SAF2014-55700-P |
dc.relation |
Ministerio de Economía y Competitividad PCIN-2013-019-C03-03 |
dc.relation |
Instituto de Salud Carlos III PIE14-00034 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-1054 |
dc.relation |
European Commission ANR-12-NEUR-0003-05 |
dc.relation |
eLife ; Vol. 6 (april 2017) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Analgesia |
dc.subject |
Optopharmacology |
dc.subject |
Pain neuraxis |
dc.subject |
Mglu5 receptor |
dc.subject |
Allosteric modulation |
dc.subject |
Mouse |
dc.title |
Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: ICREA (ICREA Academia-2010), Fundació la Marató de TV3 (Grant 20152031) and IWT (SBO-140028). |
dc.description.abstract |
Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu) receptor negative allosteric modulator raseglurant. Violet light illumination of JF-NP-26 induces a photochemical reaction prompting the active-drug's release, which effectively controls mGlu receptor activity both in ectopic expressing systems and in striatal primary neurons. Systemic administration in mice followed by local light-emitting diode (LED)-based illumination, either of the thalamus or the peripheral tissues, induced JF-NP-26-mediated light-dependent analgesia both in neuropathic and in acute/tonic inflammatory pain models. These data offer the first example of optical control of analgesia in vivo using a photocaged mGlu receptor negative allosteric modulator. This approach shows potential for precisely targeting, in time and space, endogenous receptors, which may allow a better management of difficult-to-treat disorders. |