Title:
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The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
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Author:
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Yefimenko, Natalya; Portero Tresserra, Marta; Martí Nicolovius, Margarita; Guillazo i Blanch, Gemma; Vale Martínez, Anna
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Abstract:
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Altres ajuts: PSI2011-26862 |
Abstract:
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Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose of S18986 (3 μg/site) into the prelimbic cortex, prior to olfactory discrimination acquisition, exhibited significantly shorter latencies and fewer errors to make the correct response, both in the acquisition and two drug-free retention tests. Such findings corroborate the involvement of glutamate receptors in odor-reward learning and confirm the role of the AMPAkine S18986 as a cognitive enhancer. |
Subject(s):
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-AMPA receptors -Cognitive enhancer -Glutamate -Memory facilitation -Olfactory discrimination -Prefrontal cortex |
Rights:
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open access
Tots els drets reservats.
https://rightsstatements.org/vocab/InC/1.0/ |
Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/186506
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