| Title: | Safety and pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg tablet in healthy adult volunteers |
|---|---|
| Author: | Muñoz, Jose; Ballester, Maria Rosa; Antonijoan Arbós, Rosa Ma.; Gich, Ignasi; Rodríguez, Montse; Colli, Enrico; Gold, Silvia; Krolewiecki, Alejandro J.; Universitat Autònoma de Barcelona |
| Abstract: | ClinicalTrials.gov . Current efforts for the control of poverty-related diseases provide drug treatments through mass drug administration (MDA) as a key component. Ivermectin is an antiparasitary drug which has been used to fight some of these diseases, and millions of treatments have been distributed with a favorable toxicity profile. The dosing strategy of ivermectin is based on weight, which in view of the safety characteristics of ivermectin might not be necessary, while a fix dosing strategy might improve logistics and access to the drug to those who need it. This study was conducted in healthy adult volunteers in which we compared 3 treatment regimens: the weight-based reference standard versus 2 experimental regimens of fix-dose 18 and 36 mg using 18 mg tablets. All 54 volunteers received the 3 treatments sequentially. The results confirmed that the fixed-dose regimen (both 18 mg and 36 mg) are as safe as the standard dosage and could justify the use of fix dosing regimens rather than the current weight based strategy. |
| Rights: | open access
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ |
| Document type: | Article |
| Published by: | |
| Share: |
|
| Uri: | https://ddd.uab.cat/record/187862 |
Related documents
Other documents of the same author
Muñoz, José; Ballester, Maria Rosa; Antonijoan, Rosa Maria; Gich, Ignasi; Rodriguez, Montse; Colli, Enrico; Gold, Silvia; Krolewiecki, Alejandro J.
Muñoz, José; Ballester, Maria Rosa; Antonijoan, Rosa Maria; Gich, Ignasi; Rodriguez, Montse; Colli, Enrico; Gold, Silvia; Krolewiecki, Alejandro J.
Mordmüller, Benjamin; Supan, Christian; Sim, Kim Lee; Gómez-Pérez, Gloria P.; Ospina Salazar, Carmen Lucelly; Held, Jana; Bolte, Stefanie; Esen, Meral; Tschan, Serena; Joanny, Fanny; Lamsfus Calle, Carlos; Löhr, Sascha J. Z.; Lalremruata, Albert; Gunasekera, Anusha; James, Eric R.; Billingsley, Peter F.; Richman, Adam; Chakravarty, Sumana; Legarda, Almudena; Muñoz, Jose; Antonijoan Arbós, Rosa Ma.; Ballester, Maria Rosa; Hoffman, Stephen L.; Alonso, Pedro L..; Kremsner, Peter G.; Universitat Autònoma de Barcelona
Ballester, Maria Rosa; Roig, Eulàlia; Gich, Ignasi; Puntes, Montserrat; Delgadillo, Joaquín; Santos, Benjamín; Antonijoan Arbós, Rosa Ma.; Universitat Autònoma de Barcelona
Gómez-Pérez, Gloria P.; Legarda, Almudena; Muñoz, Jose; Sim, B. Kim Lee; Ballester, Maria Rosa; Dobaño, Carlota; Moncunill, Gemma; Campo, Joseph J.; Cisteró, Pau; Jimenez, Alfons; Barrios, Diana; Mordmüller, Benjamin; Pardos, Josefina; Navarro, Mireia; Zita, Cecilia Justino; Nhamuave, Carlos Arlindo; García-Basteiro, Alberto L..; Sanz, Ariadna; Aldea, Marta; Manoj, Anita; Gunasekera, Anusha; Billingsley, Peter F.; Aponte, John J.; James, Eric R.; Guinovart, Caterina; Antonijoan Arbós, Rosa Ma.; Kremsner, Peter G.; Hoffman, Stephen L.; Alonso, Pedro L..