dc.contributor.author |
Akerman, Ildem |
dc.contributor.author |
Tu, Zhidong |
dc.contributor.author |
Beucher, Anthony |
dc.contributor.author |
Rolando, Delphine M. Y. |
dc.contributor.author |
Sauty-Colace, Claire |
dc.contributor.author |
Benazra, Marion |
dc.contributor.author |
Nakic, Nikolina |
dc.contributor.author |
Yang, Jialiang |
dc.contributor.author |
Wang, Huan |
dc.contributor.author |
Pasquali, Lorenzo |
dc.contributor.author |
Moran, Ignasi |
dc.contributor.author |
Garcia Hurtado, Javier |
dc.contributor.author |
Castro, Natalia |
dc.contributor.author |
Gonzalez Franco, Roser |
dc.contributor.author |
Stewart, Andrew F. |
dc.contributor.author |
Bonner, Caroline |
dc.contributor.author |
Piemonti, Lorenzo |
dc.contributor.author |
Berney, Thierry |
dc.contributor.author |
Groop, Leif |
dc.contributor.author |
Kerr-Conte, Julie |
dc.contributor.author |
Pattou, Francois |
dc.contributor.author |
Argmann, Carmen |
dc.contributor.author |
Schadt, Eric |
dc.contributor.author |
Ravassard, Phillipe |
dc.contributor.author |
Ferrer, Jorge |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2017 |
dc.identifier |
https://ddd.uab.cat/record/196584 |
dc.identifier |
urn:10.1016/j.cmet.2016.11.016 |
dc.identifier |
urn:oai:ddd.uab.cat:196584 |
dc.identifier |
urn:pmid:28041957 |
dc.identifier |
urn:scopus_id:85009909783 |
dc.identifier |
urn:wos_id:000396354400020 |
dc.identifier |
urn:altmetric_id:15130880 |
dc.identifier |
urn:pmc-uid:5300904 |
dc.identifier |
urn:pmcid:PMC5300904 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:5300904 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
European Commission 667191 |
dc.relation |
Ministerio de Economía y Competitividad FU2014-54284-R |
dc.relation |
Cell metabolism ; Vol. 25 (february 2017), p. 400-411 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.title |
Human Pancreatic ß Cell lncRNAs Control Cell-Specific Regulatory Networks |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: WT/WT101033 |
dc.description.abstract |
Altres ajuts: NIH-BCBC/2U01 DK072473-06 |
dc.description.abstract |
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic ß cells. ß cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in ß cell gene regulation and diabetes, the function of b cell lncRNAs remains largely unknown. In this study, we investigated the function of b cell-specific lncRNAs and transcription factors using transcript knockdowns and co-expression network analysis. This revealed lncRNAs that function in concert with transcription factors to regulate ß cell-specific transcriptional networks. We further demonstrate that the lncRNA PLUTO affects local 3D chromatin structure and transcription of PDX1, encoding a key ß cell transcription factor, and that both PLUTO and PDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance. These results implicate lncRNAs in the regulation of ß cell-specific transcription factor networks. |