dc.contributor.author |
Arrieta-Villegas, Claudia |
dc.contributor.author |
Perálvarez, Tania |
dc.contributor.author |
Vidal Barba, Enric |
dc.contributor.author |
Puighibet Maso, Zöe |
dc.contributor.author |
Moll Sánchez, Xavier |
dc.contributor.author |
Canturri, Albert |
dc.contributor.author |
Sevilla, Iker A. |
dc.contributor.author |
Espada, Yvonne |
dc.contributor.author |
Juste, Ramón A. |
dc.contributor.author |
Domingo, Mariano |
dc.contributor.author |
Pérez de Val, Bernat |
dc.date |
2018 |
dc.identifier |
https://ddd.uab.cat/record/201161 |
dc.identifier |
urn:10.1371/journal.pone.0196948 |
dc.identifier |
urn:oai:ddd.uab.cat:201161 |
dc.identifier |
urn:pmid:29742150 |
dc.identifier |
urn:recercauab:ARE-88504 |
dc.identifier |
urn:scopus_id:85046775051 |
dc.identifier |
urn:articleid:19326203v13n5e0196948 |
dc.identifier |
urn:wos_id:000431757400049 |
dc.identifier |
urn:altmetric_id:40928375 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/09279e46-9262-4279-aa1a-1825cb7e87e0 |
dc.identifier |
urn:pmc-uid:5942842 |
dc.identifier |
urn:pmcid:PMC5942842 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:5942842 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
PloS one ; Vol. 13 Núm. 5 (may 2018), p. e0196948 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Animals |
dc.subject |
BCG Vaccine |
dc.subject |
Goats |
dc.subject |
Hot Temperature |
dc.subject |
Lung |
dc.subject |
Mycobacterium bovis |
dc.subject |
Tuberculosis |
dc.subject |
Vaccination |
dc.subject |
Vaccines, Inactivated |
dc.title |
Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats |
dc.type |
Article |
dc.description.abstract |
Tuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that causes large economic losses in livestock. Goats are particularly susceptible to TB and, in endemic areas, vaccination may be a valuable measure to control the disease. The main aim of this study was to evaluate the efficacy of parenteral vaccination of goats with a heat-inactivated Mycobacterium bovis (HIMB) vaccine, and compare it to M. bovis Bacille Calm-ette-Guérin (BCG) vaccine. Twenty-four goat kids were divided in 3 groups as following: HIMB vaccinated group (n = 8), BCG vaccinated group (n = 8) and unvaccinated group (n = 8). Afterwards, goats were experimentally challenged with Mycobacterium caprae by the endobronchial route. Antigen specific interferon-γ release assays and serology were performed after vaccination and challenge. Pathological and bacteriological parameters were evaluated after necropsy at 9 weeks post-challenge (p.c.). HIMB vaccine showed similar levels of protection to BCG in terms of volume reduction of thoracic TB lesions, presence of extra-pulmonary lesions, as well as a slight reduction of bacterial load in pulmonary lymph nodes. Moreover, HIMB vaccine did not induce interferences on the interferon-γ release assay based on reagents previously developed to differentiate infected from BCG vaccinated individuals. The results indicate that HIMB is a suitable vaccine candidate for further larger-scale trials under field conditions in goats. |