Title:
|
Airborne copper exposure in school environments associated with poorer motor performance and altered basal ganglia
|
Author:
|
Pujol Nuez, Jesús; Fenoll, Raquel; Macià, Dídac; Martínez Vilavella, Gerard; Álvarez Pedrerol, Mar; Rivas Lara, Ioar; Forns, Joan; Deus Yela, Juan; Blanco Hinojo, Laura; Querol Carceller, Xavier; Sunyer Deu, Jordi
|
Abstract:
|
Children are more vulnerable to the effects of environmental elements. A variety of air pollutants are among the identified factors causing neural damage at toxic concentrations. It is not obvious, however, to what extent the tolerated high levels of air pollutants are able to alter brain development. We have specifically investigated the neurotoxic effects of airborne copper exposure in school environments. Speed and consistency of motor response were assessed in 2836 children aged from 8 to 12 years. Anatomical , diffusion tensor imaging, and functional were used to directly test the brain repercussions in a subgroup of 263 children. Higher copper exposure was associated with poorer motor performance and altered structure of the basal ganglia. Specifically, the architecture of the caudate nucleus region was less complete in terms of both tissue composition and neural track water diffusion. Functional consistently showed a reciprocal connectivity reduction between the caudate nucleus and the frontal cortex. The results establish an association between environmental copper exposure in children and alterations of basal ganglia structure and function. |
Subject(s):
|
-Air pollution -Brain development -Copper -Diffusion tensor imaging -Neurodegenerative disorders |
Rights:
|
open access
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
https://creativecommons.org/licenses/by/4.0/ |
Document type:
|
Article |
Published by:
|
|
Share:
|
|
Uri:
|
https://ddd.uab.cat/record/201465
|