Title:
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Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder : study protocol for a randomized clinical trial
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Author:
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Vicent-Gil, Muriel; Raventós, Beatriz; Marín-Martínez, Eduardo D.; González-Simarro, Sara; Martínez-Arán, Anabel; Bonnin, Caterina del Mar; Trujols, Joan; Pérez-Blanco, Josefina; de Diego-Adeliño, Javier; Puigdemont, Dolors; Serra-Blasco, Maria; Cardoner, N. (Narcís); Portella, Maria J..
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Abstract:
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Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Clinical Trials . Date registered 10th of August 2018 and last updated 24th August 2018. |
Subject(s):
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-Cognitive remediation -Depression -Functional remediation -Computerized cognitive training -Clinical trial |
Rights:
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open access
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Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/226449
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