Title:
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Evolution of the gut microbiome following acute HIV-1 infection
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Author:
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Rocafort, Muntsa; Noguera-Julian, Marc; Rivera Pinto, Javier; Pastor, Lucía; Guillén Montalbán, Yolanda; Langhorst, Jost; Parera, Mariona; Mandomando, Inacio; Carrillo, Jorge; Urrea, Víctor; Rodríguez, Cristina; Casadellà, Maria; Calle, M. Luz; Pérez-Álvarez, Núria; Blanco, Julià; Naniche, Denise; Paredes, Roger; Universitat Autònoma de Barcelona
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Abstract:
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In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand the longitudinal effects of HIV-1 infection on the human gut microbiota, we prospectively followed 49 Mozambican subjects diagnosed with recent HIV-1 infection (RHI) and 54 HIV-1-negative controls for 9-18 months and compared them with 98 chronically HIV-1-infected subjects treated with antiretrovirals (n = 27) or not (n = 71). We show that RHI is followed by increased fecal adenovirus shedding, which persists during chronic HIV-1 infection and does not resolve with ART. Recent HIV-1 infection is also followed by transient non-HIV-specific changes in the gut bacterial richness and composition. Despite early resilience to change, an HIV-1-specific signature in the gut bacteriome-featuring depletion of Akkermansia, Anaerovibrio, Bifidobacterium, and Clostridium- previously associated with chronic inflammation, CD8+ T cell anergy, and metabolic disorders, can be eventually identified in chronically HIV-1-infected subjects. Recent HIV-1 infection is associated with increased fecal shedding of eukaryotic viruses, transient loss of bacterial taxonomic richness, and long-term reductions in microbial gene richness. An HIV-1-associated microbiome signature only becomes evident in chronically HIV-1-infected subjects. The online version of this article (10.1186/s40168-019-0687-5) contains supplementary material, which is available to authorized users. |
Subject(s):
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-Microbiome -HIV-1 -Acute HIV-1 infection -HIV-1 pathogenesis -AIDS |
Rights:
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open access
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https://creativecommons.org/licenses/by/4.0/ |
Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/226459
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