dc.contributor.author |
Gabriel Salazar, Marina |
dc.contributor.author |
Morancho, Anna |
dc.contributor.author |
Rodriguez, Susana |
dc.contributor.author |
Buxo Masip, Xavier |
dc.contributor.author |
García-Rodríguez, Nicolás |
dc.contributor.author |
Colell, Guillem |
dc.contributor.author |
Fernandez, Albert |
dc.contributor.author |
Giralt, Dolors |
dc.contributor.author |
Bustamante, Alejandro |
dc.contributor.author |
Montaner, Joan |
dc.contributor.author |
Rosell Novel, Anna |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2018 |
dc.identifier |
https://ddd.uab.cat/record/253589 |
dc.identifier |
urn:10.3389/fneur.2018.00508 |
dc.identifier |
urn:oai:ddd.uab.cat:253589 |
dc.identifier |
urn:pmcid:PMC6034071 |
dc.identifier |
urn:pmc-uid:6034071 |
dc.identifier |
urn:pmid:30008694 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6034071 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Economía y Competitividad JR16/00008 |
dc.relation |
Ministerio de Economía y Competitividad II15/00003 |
dc.relation |
Ministerio de Economía y Competitividad PI13/01094 |
dc.relation |
Ministerio de Economía y Competitividad PI16/00981 |
dc.relation |
Ministerio de Economía y Competitividad RD12/0014/0005 |
dc.relation |
Frontiers in neurology ; Vol. 9 (june 2018) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Stroke |
dc.subject |
Rehabilitation |
dc.subject |
Angiogenesis |
dc.subject |
Angiogenin |
dc.subject |
Endothelial progenitor cell |
dc.subject |
Biomarker |
dc.title |
Importance of Angiogenin and Endothelial Progenitor Cells After Rehabilitation Both in Ischemic Stroke Patients and in a Mouse Model of Cerebral Ischemia |
dc.type |
Article |
dc.description.abstract |
Background: Rehabilitation therapy is the only available treatment for stroke survivors presenting neurological deficits; however, the underlying molecules and mechanisms associated with functional/motor improvement during rehabilitation are poorly understood. Objective: Our aim is to study the modulation of angiogenin and endothelial progenitor cells (EPCs) as repair-associated factors in a cohort of stroke patients and mouse models of rehabilitation after cerebral ischemia. Methods: The clinical study included 18 ischemic strokes admitted to an intensive rehabilitation therapy (IRT) unit, 18 non-ischemic controls and brain samples from three deceased patients. Angiogenin and EPCs were measured in blood obtained before and up to 6 months after IRT together with an extensive evaluation of the motor/functional status. In parallel, C57BL/6 mice underwent middle cerebral artery occlusion, and the pasta matrix reaching-task or treadmill exercises were used as rehabilitation models. Angiogenin RNA expression was measured after 2 or 12 days of treatment together with cell counts from EPCs cultures. Results: Brain angiogenin was identified in both human and mouse tissue, whereas serum levels increased after 1 month of IRT in association with motor/functional improvement. EPC populations were increased after stroke and remained elevated during follow-up after IRT. The mouse model of rehabilitation by the task-specific pasta matrix exercise increased the number of EPCs at 2 days and increased angiogenin expression after 12 days of rehabilitation. Conclusions: Angiogenin and EPCs are modulated by rehabilitation after cerebral ischemia, suggesting that both angiogenin and EPCs could serve as biomarkers of improvement during rehabilitation or future therapeutic targets |