dc.contributor.author |
Garriga, César |
dc.contributor.author |
García de Olalla, Patricia |
dc.contributor.author |
Miró, Josep M. |
dc.contributor.author |
Ocaña Rivera, Immaculada |
dc.contributor.author |
Knobel Freud, Hernando |
dc.contributor.author |
Barbera, María Jesus |
dc.contributor.author |
Humet, Victoria |
dc.contributor.author |
Domingo, Pere |
dc.contributor.author |
Gatell, Josep M.. |
dc.contributor.author |
Ribera, Esteve |
dc.contributor.author |
Gurguí, Mercè |
dc.contributor.author |
Marco, Andrés |
dc.contributor.author |
Caylà, Joan A.. |
dc.date |
2015 |
dc.identifier |
https://ddd.uab.cat/record/254508 |
dc.identifier |
urn:10.1371/journal.pone.0145701 |
dc.identifier |
urn:oai:ddd.uab.cat:254508 |
dc.identifier |
urn:pmcid:PMC4696823 |
dc.identifier |
urn:pmc-uid:4696823 |
dc.identifier |
urn:pmid:26716982 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:4696823 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/5863761c-b148-4bd9-b740-c55d9025d33f |
dc.identifier |
urn:scopus_id:84957075541 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III 12/PEAC-06 |
dc.relation |
PloS one ; Vol. 10 (december 2015) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.title |
Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort |
dc.type |
Article |
dc.description.abstract |
Antiretroviral therapy has led to a decrease in HIV-related mortality and to the emergence of non-AIDS defining diseases as competing causes of death. This study estimates the HIV mortality rate and their risk factors with regard to different causes in a large city from January 2001 to June 2013. We followed-up 3137 newly diagnosed HIV non-AIDS cases. Causes of death were classified as HIV-related, non-HIV-related and external. We examined the effect of risk factors on survival using mortality rates, Kaplan-Meier plots and Cox models. Finally, we estimated survival for each main cause of death groups through Fine and Gray models. 182 deaths were found [14.0/1000 person-years of follow-up (py); 95% confidence interval (CI):12.0-16.1/1000 py], 81.3% of them had a known cause of death. Mortality rate by HIV-related causes and non-HIV-related causes was the same (4.9/1000 py; CI:3.7-6.1/1000 py), external was lower [1.7/1000 py; (1.0-2.4/1000 py)]. Kaplan-Meier estimate showed worse survival in intravenous drug user (IDU) and heterosexuals than in men having sex with men (MSM). Factors associated with HIV-related causes of death include: IDU male (subHazard Ratio (sHR):3.2; CI:1.5-7.0) and <200 CD4 at diagnosis (sHR:2.7; CI:1.3-5.7) versus ≥500 CD4. Factors associated with non-HIV-related causes of death include: ageing (sHR:1.5; CI:1.4-1.7) and heterosexual female (sHR:2.8; CI:1.1-7.3) versus MSM. Factors associated with external causes of death were IDU male (sHR:28.7; CI:6.7-123.2) and heterosexual male (sHR:11.8; CI:2.5-56.4) versus MSM. There are important differences in survival among transmission groups. Improved treatment is especially necessary in IDUs and heterosexual males. |