Title:
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Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
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Author:
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Hernáez, Álvaro; Lassale, Camille; Castro-Barquero, Sara; Ros Rahola, Emilio; Tresserra i Rimbau, Anna; Castañer, Olga; Pintó Sala, Xavier; Vázquez Ruiz, Zenaida; Sorlí, José V.; Salas Salvadó, Jordi; Lapetra, José; Gómez-Gracia, Enrique; Alonso Gómez, Ángel M.; Fiol, Miquel; Serra Majem, Lluís; Sacanella Meseguer, Emilio; Razquin, Cristina; Corella Piquer, Dolores; Guasch-Ferré, Marta; Cofán Pujol, Montserrat; Estruch Riba, Ramon
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Other authors:
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Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna |
Abstract:
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There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk. |
Publication date:
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2021-02 |
Subject (UDC):
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613 - Higiene en general. Higiene i salut personal 616.1 - Patologia del sistema circulatori, dels vasos sanguinis. Trastorns cardiovasculars |
Subject(s):
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Dieta mediterrània Plaquetes sanguínies --Trastorns Trombocitopènia -- Prevenció |
Rights:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by/4.0/
© L'autor/a |
Pages:
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13 p. |
Document type:
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Article Article - Published version |
DOI:
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https://doi.org/10.3390/nu13020559
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Published by:
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MDPI
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Publish at:
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Nutrients, 2021, 13, 559
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Share:
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