The "Canine Leishmaniasis Working Group"(CLWG) has elaborated guidelines for the diagnosis of canine leishmaniasis, its classification and the treatment of affected dogs with concurrent proteinuria. The guidelines are based on existing references and/or the experience of the CLWG members. The paper aims to provide the most updated information about the treatment of dogs affected by leishmaniasis. The veterinary clinician should critically evaluate the potential applicability of the present guidelines when treating cases of canine leishmaniasis.