To access the full text documents, please follow this link: http://hdl.handle.net/2445/122159

Title:	Effect of oral anticoagulants on the outcome of faecal immunochemical test
Author:	Bujanda, Luis; Sarasqueta, Cristina; Lanas, Angel; Quintero, Enrique; Cubiella, Joaquín; Hernández, Vicent; Morillas, Juan D.; Perez-Fernández, T.; Salas, D.; Andreu, Montserrat; Carballo, F.; Bessa i Caserras, Xavier; Portillo, I.; Jover, Rodrigo; Balaguer Prunés, Francesc; Cosme, Ángel; Castells Garangou, Antoni
Notes:	Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend ¼ 0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P ¼ 0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P ¼ 0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.
Subject(s):	-Càncer colorectal -Anticoagulants (Medicina) -Immunoquímica -Colonoscòpia -Estudi de casos -Colorectal cancer -Anticoagulants (Medicine) -Immunochemistry -Colonoscopy -Case studies
Rights:	cc-by-nc-sa (c) Bujanda, Luis et al., 2014 http://creativecommons.org/licenses/by-nc-sa/3.0/es
Document type:	Article Article - Published version
Published by:	Cancer Research UK
Share:

Show full item record