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| dc.contributor.author | Ortiz Pérez, José Tomás |
|---|---|
| dc.contributor.author | Riera, Marta |
| dc.contributor.author | Bosch Genover, Xavier |
| dc.contributor.author | Caralt Robira, Ma. Teresa de |
| dc.contributor.author | Perea Palazón, Rosario Jesús |
| dc.contributor.author | Pascual, Julio (Pascual Santos) |
| dc.contributor.author | Soler, María José |
| dc.date | 2018-07-24T10:49:48Z |
| dc.date | 2018-07-24T10:49:48Z |
| dc.date | 2013-04-22 |
| dc.date | 2018-07-24T10:49:49Z |
| dc.identifier | 1932-6203 |
| dc.identifier | 642372 |
| dc.identifier | 23630610 |
| dc.identifier.uri | http://hdl.handle.net/2445/123864 |
| dc.description | Angiotensin-converting enzyme 2 (ACE2) cleaves Angiotensin-II to Angiotensin-(1-7), a cardioprotective peptide. Serum soluble ACE2 (sACE2) activity is raised in chronic heart failure, suggesting a compensatory role in left ventricular dysfunction. Our aim was to study the relationship between sACE2 activity, infarct size, left ventricular systolic function and remodeling following ST-elevation myocardial infarction (STEMI). A contrast-enhanced cardiac magnetic resonance study was performed acutely in 95 patients with first STEMI and repeated at 6 months to measure LV end-diastolic volume index, ejection fraction and infarct size. Baseline sACE2 activities, measured by fluorescent enzymatic assay 24 to 48 hours and at 7 days from admission, were compared to that obtained in 22 matched controls. Patients showed higher sACE2 at baseline than controls (104.4 [87.4-134.8] vs 74.9 [62.8-87.5] RFU/µl/hr, p<0.001). At seven days, sACE2 activity significantly increased from baseline (115.5 [92.9-168.6] RFU/µl/hr, p<0.01). An inverse correlation between sACE2 activity with acute and follow-up ejection fraction was observed (r = −0.519, p<0.001; r = −0.453, p = 0.001, respectively). Additionally, sACE2 directly correlated with infarct size (r = 0.373, p<0.001). Both, infarct size (β = −0.470 [95%CI:−0.691:−0.248], p<0.001) and sACE2 at 7 days (β = −0.025 [95%CI:−0.048:−0.002], p = 0.030) were independent predictors of follow-up ejection fraction. Patients with sACE2 in the upper tertile had a 4.4 fold increase in the incidence of adverse left ventricular remodeling (95% confidence interval: 1.3 to 15.2, p = 0.027). In conclusion, serum sACE2 activity rises in relation to infarct size, left ventricular systolic dysfunction and is associated with the occurrence of left ventricular remodeling. |
| dc.format | 8 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0061695 |
| dc.relation | PLoS One, 2013, vol. 8, num. 4, p. 1-8 |
| dc.relation | https://doi.org/10.1371/journal.pone.0061695 |
| dc.rights | cc-by (c) Ortiz Pérez, José Tomás et al., 2013 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Angiotensines |
| dc.subject | Infart de miocardi |
| dc.subject | Ventricles cardíacs |
| dc.subject | Angiotensins |
| dc.subject | Myocardial infarction |
| dc.subject | Ventricle of heart |
| dc.title | Role of Circulating Angiotensin Converting Enzyme 2 in Left Ventricular Remodeling following Myocardial Infarction: A Prospective Controlled Study. |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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