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dc.contributor.author | Jalan, Rajiv |
---|---|
dc.contributor.author | Pavesi, Marco |
dc.contributor.author | Saliba, Faouzi |
dc.contributor.author | Amorós, Àlex |
dc.contributor.author | Fernández, Javier |
dc.contributor.author | Holland-Fischer, Peter |
dc.contributor.author | Sawhney, Rohit |
dc.contributor.author | Mookerjee, Rajeshwar P. |
dc.contributor.author | Caraceni, Paolo |
dc.contributor.author | Moreau, Richard |
dc.contributor.author | Ginès i Gibert, Pere |
dc.contributor.author | Durand, François |
dc.contributor.author | Angeli, Paolo |
dc.contributor.author | Alessandria, Carlo |
dc.contributor.author | Laleman, Wim |
dc.contributor.author | Trebicka, Jonel |
dc.contributor.author | Samuel, Didier |
dc.contributor.author | Zeuzem, Stefan |
dc.contributor.author | Gustot, Thierry |
dc.contributor.author | Gerbes, A. L. (Alexander L.) |
dc.contributor.author | Wendon, Julia |
dc.contributor.author | Bernardi, Mauro |
dc.contributor.author | Arroyo, Vicente |
dc.date | 2018-10-08T14:28:28Z |
dc.date | 2018-10-08T14:28:28Z |
dc.date | 2015-04-30 |
dc.date | 2018-10-08T14:28:28Z |
dc.identifier | 0168-8278 |
dc.identifier | 644976 |
dc.identifier | 25463539 |
dc.identifier.uri | http://hdl.handle.net/2445/125144 |
dc.description | BACKGROUND & AIMS: Cirrhotic patients with acute decompensation frequently develop acute-on-chronic liver failure (ACLF), which is associated with high mortality rates. Recently, a specific score for these patients has been developed using the CANONIC study database. The aims of this study were to develop and validate the CLIF-C AD score, a specific prognostic score for hospitalised cirrhotic patients with acute decompensation (AD), but without ACLF, and to compare this with the Child-Pugh, MELD, and MELD-Na scores. METHODS: The derivation set included 1016 CANONIC study patients without ACLF. Proportional hazards models considering liver transplantation as a competing risk were used to identify score parameters. Estimated coefficients were used as relative weights to compute the CLIF-C ADs. External validation was performed in 225 cirrhotic AD patients. CLIF-C ADs was also tested for sequential use. RESULTS: Age, serum sodium, white-cell count, creatinine and INR were selected as the best predictors of mortality. The C-index for prediction of mortality was better for CLIF-C ADs compared with Child-Pugh, MELD, and MELD-Nas at predicting 3- and 12-month mortality in the derivation, internal validation and the external dataset. CLIF-C ADs improved in its ability to predict 3-month mortality using data from days 2, 3-7, and 8-15 (C-index: 0.72, 0.75, and 0.77 respectively). CONCLUSIONS: The new CLIF-C ADs is more accurate than other liver scores in predicting prognosis in hospitalised cirrhotic patients without ACLF. CLIF-C ADs therefore may be used to identify a high-risk cohort for intensive management and a low-risk group that may be discharged early. |
dc.format | 24 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Elsevier |
dc.relation | Versió postprint del document publicat a: https://doi.org/10.1016/j.jhep.2014.11.012 |
dc.relation | Journal of Hepatology, 2015, vol. 62, num. 4, p. 831-840 |
dc.relation | https://doi.org/10.1016/j.jhep.2014.11.012 |
dc.rights | (c) Elsevier, 2015 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Cirrosi hepàtica |
dc.subject | Malalties del fetge |
dc.subject | Pronòstic mèdic |
dc.subject | Hepatic cirrhosis |
dc.subject | Liver diseases |
dc.subject | Prognosis |
dc.title | The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/acceptedVersion |