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Title:	Impact of Region-of-Interest Delineation Methods, Reconstruction Algorithms, and Intra- and Inter-Operator Variability on Internal Dosimetry Estimates Using PET
Author:	López Vilanova, N.; Pavía Segura, Javier; Duch Guillén, Ma. Amor (María Amor); Catafau Alcántara, Ana Ma.; Ros Puig, Domènec; Bullich Roig, Santiago
Notes:	Purpose: Human dosimetry studies play a central role in radioligand development for positron emission tomography (PET). Drawing regions of interest (ROIs) on the PET images is used to measure the dose in each organ. In the study aspects related to ROI delineation methods were evaluated for two radioligands of different biodistribution (intestinal vs urinary). Procedures: PET images were simulated from a human voxel-based phantom. Several ROI delineation methods were tested: antero-posterior projections (AP), 3D sub-samples of the organs (S), and a 3D volume covering the whole-organ (W). Inter- and intra-operator variability ROI drawing was evaluated by using human data. Results: The effective dose estimates using S and W methods were comparable to the true values. AP methods overestimated (49 %) the dose for the radioligand with intestinal biodistribution. Moreover, the AP method showed the highest inter-operator variability: 11 ± 1 %. Conclusions: The sub-sampled organ method showed the best balance between quantitative accuracy and inter- and intra-operator variability.
Subject(s):	-Dosimetria (Radiació) -Radiation dosimetry
Rights:	(c) Academy of Molecular Imaging; European Society for Molecular Imaging; Society for Molecular Imaging, 2017
Document type:	Article Article - Accepted version
Published by:	Springer Verlag
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