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dc.contributor.author | Benito, Eva |
---|---|
dc.contributor.author | Cabanelas, Nuno |
dc.contributor.author | Nuñez-Garcia, Marta |
dc.contributor.author | Alarcón, Francisco |
dc.contributor.author | Figueras i Ventura, Rosa M. |
dc.contributor.author | Soto-Iglesias, David |
dc.contributor.author | Guasch i Casany, Eduard |
dc.contributor.author | Prat González, Susanna |
dc.contributor.author | Perea Palazón, Rosario Jesús |
dc.contributor.author | Borràs, Roger |
dc.contributor.author | Butakoff, Constantine |
dc.contributor.author | Camara, Oscar |
dc.contributor.author | Bisbal, Felipe |
dc.contributor.author | Arbelo, Elena |
dc.contributor.author | Tolosana, José María |
dc.contributor.author | Brugada Terradellas, Josep, 1958- |
dc.contributor.author | Berruezo Sánchez, Antonio |
dc.contributor.author | Mont Girbau, Lluís |
dc.date | 2019-04-11T12:47:31Z |
dc.date | 2019-12-31T06:10:16Z |
dc.date | 2018-12-01 |
dc.date | 2019-04-11T12:47:31Z |
dc.identifier | 1099-5129 |
dc.identifier | 685960 |
dc.identifier | 29860416 |
dc.identifier.uri | http://hdl.handle.net/2445/132064 |
dc.description | Aims: Left atrial (LA) fibrosis can be identified by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) in patients with atrial fibrillation (AF). However, there is limited information about anatomical fibrosis distribution in the left atrium. The aim is to determine whether there is a preferential spatial distribution of fibrosis in the left atrium in patients with AF. Methods and results: A 3-Tesla LGE-CMR was performed in 113 consecutive patients referred for AF ablation. Images were post-processed and analysed using ADAS-AF software (Galgo Medical), which allows fibrosis identification in 3D colour-coded shells. A regional semiautomatic LA parcellation software was used to divide the atrial wall into 12 segments: 1-4, posterior wall; 5-6, floor; 7, septal wall; 8-11, anterior wall; 12, lateral wall. The presence and amount of fibrosis in each segment was obtained for analysis. After exclusions for artefacts and insufficient image quality, 76 LGE-MRI images (68%) were suitable for fibrosis analysis. Segments 3 and 5, closest to the left inferior pulmonary vein, had significantly higher fibrosis (40.42% ± 23.96 and 25.82% ± 21.24, respectively; P < 0.001), compared with other segments. Segments 8 and 10 in the anterior wall contained the lowest fibrosis (2.54% ± 5.78 and 3.82% ± 11.59, respectively; P < 0.001). Age >60 years was significantly associated with increased LA fibrosis [95% confidence interval (CI) 0.19-8.39, P = 0.04] and persistent AF approached significance (95% CI -0.19% to 7.83%, P = 0.08). Conclusion: In patients with AF, the fibrotic area is preferentially located at the posterior wall and floor around the antrum of the left inferior pulmonary vein. Age >60 years was associated with increased fibrosis. |
dc.format | 31 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Oxford University Press |
dc.relation | Versió postprint del document publicat a: https://doi.org/10.1093/europace/euy095 |
dc.relation | Europace, 2018, vol. 20, num. 12, p. 1959-1965 |
dc.relation | https://doi.org/10.1093/europace/euy095 |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/633196/EU//CATCH ME |
dc.rights | (c) Benito, Eva et al., 2018 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Ressonància magnètica |
dc.subject | Malalties del cor |
dc.subject | Fibril·lació auricular |
dc.subject | Magnetic resonance |
dc.subject | Heart diseases |
dc.subject | Atrial fibrillation |
dc.title | Preferential regional distribution of atrial fibrosis in posterior wall around left inferior pulmonary vein as identified by late gadolinium enhancement cardíac magnetic resonance in patients with atrial fibrillation |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/acceptedVersion |