To access the full text documents, please follow this link: http://hdl.handle.net/2445/148044
dc.contributor.author | Baliakas, Panagiotis |
---|---|
dc.contributor.author | Moysiadis, Theodoros |
dc.contributor.author | Hadzidimitriou, Anastasia |
dc.contributor.author | Xochelli, Aliki |
dc.contributor.author | Jeromin, Sabine |
dc.contributor.author | Agathangelidis, Andreas |
dc.contributor.author | Mattsson, Mattias |
dc.contributor.author | Sutton, Lesley-Ann |
dc.contributor.author | Minga, Eva |
dc.contributor.author | Scarfò, Lydia |
dc.contributor.author | Rossi, Davide |
dc.contributor.author | Davis, Zadie |
dc.contributor.author | Villamor i Casas, Neus |
dc.contributor.author | Parker, Helen |
dc.contributor.author | Kotaskova, Jana |
dc.contributor.author | Stalika, Evangelia |
dc.contributor.author | Plevova, Karla |
dc.contributor.author | Mansouri, Larry |
dc.contributor.author | Cortese, Diego |
dc.contributor.author | Navarro López, Alba |
dc.contributor.author | Delgado, Julio (Delgado González) |
dc.contributor.author | Larrayoz, Marta |
dc.contributor.author | Young, Emma |
dc.contributor.author | Anagnostopoulos, Achilles |
dc.contributor.author | Smedby, Karin E. |
dc.contributor.author | Juliusson, Gunnar |
dc.contributor.author | Sheehy, Oonagh |
dc.contributor.author | Catherwood, Mark |
dc.contributor.author | Strefford, Jonathan C. |
dc.contributor.author | Stavroyianni, Niki |
dc.contributor.author | Belessi, Chrysoula |
dc.contributor.author | Pospisilova, Sarka |
dc.contributor.author | Oscier, David |
dc.contributor.author | Gaidano, Gianluca |
dc.contributor.author | Campo Güerri, Elias |
dc.contributor.author | Haferlach, Claudia |
dc.contributor.author | Ghia, Paolo |
dc.contributor.author | Rosenquist, Richard |
dc.contributor.author | Stamatopoulos, Kostas |
dc.date | 2020-01-16T14:47:22Z |
dc.date | 2020-01-16T14:47:22Z |
dc.date | 2019-02 |
dc.date | 2020-01-16T14:47:22Z |
dc.identifier | 0390-6078 |
dc.identifier | 682535 |
dc.identifier | 4213867 |
dc.identifier.uri | http://hdl.handle.net/2445/148044 |
dc.description | Chronic lymphocytic leukemia (CLL) patients with differentialsomatic hypermutation status of the immunoglobulin heavy vari-able genes, namely mutated or unmutated, display fundamentalclinico-biological differences. Considering this, we assessed prognosisseparately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015patients, hypothesizing that the relative significance of relevant indica-tors may differ between these two categories. Within Binet A M-CLLpatients, besides TP53abnormalities, trisomy 12 and stereotyped subset#2 membership were equivalently associated with the shortest time-to-first-treatment and a treatment probability at five and ten years afterdiagnosis of 40% and 55%, respectively; the remaining cases exhibited5-year and 10-year treatment probability of 12% and 25%, respectively.Within Binet A U-CLL patients, besides TP53abnormalities, del(11q)and/or SF3B1mutations were associated with the shortest time-to-first-treatment (5- and 10-year treatment probability: 78% and 98%, respec-tively); in the remaining cases, males had a significantly worse prognosisthan females. In conclusion, the relative weight of indicators that canaccurately risk stratify early-stage CLL patients differs depending on thesomatic hypermutation status of the immunoglobulin heavy variablegenes of each patient. This finding highlights the fact that compartmen-talized approaches based on immunogenetic features are necessary torefine and tailor prognostication in CLL. |
dc.format | 10 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Ferrata Storti Foundation |
dc.relation | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2018.195032 |
dc.relation | Haematologica, 2019, vol. 104, num. 2, p. 360-369 |
dc.relation | https://doi.org/10.3324/haematol.2018.195032 |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/692298/EU//MEDGENET |
dc.rights | (c) Ferrata Storti Foundation, 2018 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Leucèmia limfocítica crònica |
dc.subject | Pronòstic mèdic |
dc.subject | Chronic lymphocytic leukemia |
dc.subject | Prognosis |
dc.title | Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia. |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |