Aggressiveness in depression: a neglected symptom possibly associated with bipolarity and mixed features

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

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dc.contributor.author	Verdolini, Norma
dc.contributor.author	Perugi, Giulio
dc.contributor.author	Samalin, Ludovic
dc.contributor.author	Murru, Andrea
dc.contributor.author	Angst, Jules
dc.contributor.author	Azorin, Jean-Michel
dc.contributor.author	Bowden, Charles L.
dc.contributor.author	Mosolov, Sergey
dc.contributor.author	Young, Allan H.
dc.contributor.author	Barbuti, Margherita
dc.contributor.author	Guiso, Giovanni
dc.contributor.author	Popovic, Dina
dc.contributor.author	Vieta i Pascual, Eduard, 1963-
dc.contributor.author	Pacchiarotti, Isabella
dc.contributor.author	BRIDGE-II-Mix Study Group
dc.date	2020-01-20T14:54:33Z
dc.date	2020-01-20T14:54:33Z
dc.date	2017-10
dc.date	2020-01-20T14:54:33Z
dc.identifier	0001-690X
dc.identifier	673076
dc.identifier.uri	http://hdl.handle.net/2445/148241
dc.description	OBJECTIVE: To evaluate aggressiveness during a major depressive episode (MDE) and its relationship with bipolar disorder (BD) in a post hoc analysis of the BRIDGE-II-MIX study. METHOD: A total of 2811 individuals were enrolled in this multicenter cross-sectional study. MDE patients with (MDE-A, n = 399) and without aggressiveness (MDE-N, n = 2412) were compared through chi-square test or Student's t-test. A stepwise backward logistic regression model was performed. RESULTS: MDE-A group was more frequently associated with BD (P < 0.001), while aggressiveness was negatively correlated with unipolar depression (P < 0.001). At the logistic regression, aggressiveness was associated with the age at first depressive episode (P < 0.001); the severity of mania (P = 0.03); the diagnosis of BD (P = 0.001); comorbid borderline personality disorder (BPD) (P < 0.001) but not substance abuse (P = 0.63); no current psychiatric treatment (P < 0.001); psychotic symptoms (P = 0.007); the marked social/occupational impairment (P = 0.002). The variable most significantly associated with aggressiveness was the presence of DSM-5 mixed features (P < 0.001, OR = 3.815). After the exclusion of BPD, the variable of lifetime suicide attempts became significant (P = 0.013, OR = 1.405). CONCLUSION: Aggressiveness seems to be significantly associated with bipolar spectrum disorders, independently from BPD and substance abuse. Aggressiveness should be considered as a diagnostic criterion for the mixed features specifier and a target of tailored treatment strategy.
dc.format	30 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	John Wiley & Sons
dc.relation	Versió postprint del document publicat a: https://doi.org/10.1111/acps.12777
dc.relation	Acta Psychiatrica Scandinavica, 2017, vol. 136, num. 4, p. 362-372
dc.relation	https://doi.org/10.1111/acps.12777
dc.rights	(c) John Wiley & Sons, 2017
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Trastorn bipolar
dc.subject	Depressió psíquica
dc.subject	Agressivitat
dc.subject	Manic-depressive illness
dc.subject	Mental depression
dc.subject	Aggressiveness
dc.title	Aggressiveness in depression: a neglected symptom possibly associated with bipolarity and mixed features
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion

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