https://hdl.handle.net/2072/451668 2026-04-09T23:18:17Z https://hdl.handle.net/11351/13130 Fundamentals of lipoprotein(a) request and quantification in the clinical laboratory ARROBAS VELILLA, TERESA; Fernández Prendes, Carla; Calmarza, Pilar; Camós Anguila, Sílvia; Candás-Estébanez, Beatriz; Castro-Castro, Maria Jose; Ceacero-Marín, David; Amigó, Núria Colesterol; Lipoproteïna A; Colesterol; Lipoproteína(a); Cholesterol; Lipoprotein(a); Cardiovascular diseases keep being the leading cause of mortality in Spain. Efforts should be intensified to identify new risk factors that may contribute to increasing cardiovascular risk. Lipoprotein(a) (Lp(a)) has been associated with a higher risk for developing aortic valve stenosis, heart failure, ischemic stroke, ischemic heart disease and peripheral arterial disease. Hyperlipoproteinemia(a) is a common health problem. Between 10 and 30 % of the world population have Lp(a) values exceeding 50 mg/dL. The scientific evidence provided in the recent years confirms an independent association between Lp(a) and the risk for having an arteriosclerotic cardiovascular event. This finding, added to the emergence of new specific therapies for reducing Lp(a) has raised interest in the quantification of this lipoprotein. The objective of this paper was to perform a review of the evidence available to identify the patients who will benefit from undergoing Lp(a) testing and determine the recommended quantification methods, the desirable concentrations, and the role of Lp(a) determination in reclassifying the cardiovascular risk of patients. 2025-05-26T07:14:24Z https://hdl.handle.net/11351/7104 Bronchial Thermoplasty Global Registry (BTGR): 2-year results Herth, Felix J.; Munoz-Fernandez, Ana M.; Puente, Luis; Facciolongo, Nicola; Bicknell, Stephen; Torrego, Alfons Asma; Broncoscòpia; Termoplàstia bronquial; Asma; Broncoscopia; Termoplastia bronquial; Asthma; Bronchoscopy; Bronchial Thermoplasty; Objectives: Bronchial thermoplasty (BT) is a device-based treatment for subjects ≥18 years with severe asthma not well controlled with inhaled corticosteroids and long-acting beta-agonists. The Bronchial Thermoplasty Global Registry (BTGR) collected real-world data on subjects undergoing this procedure. Design: The BTGR is an all-comer, prospective, open-label, multicentre study enrolling adult subjects indicated for and treated with BT. Setting: Eighteen centres in Spain, Italy, Germany, the UK, the Netherlands, the Czech Republic, South Africa and Australia PARTICIPANTS: One hundred fifty-seven subjects aged 18 years and older who were scheduled to undergo BT treatment for asthma. Subjects diagnosed with other medical conditions which, in the investigator's opinion, made them inappropriate for BT treatment were excluded. Primary and secondary outcome measures: Baseline characteristics collected included demographics, Asthma Quality of Life Questionnaire (AQLQ), Asthma Control Test (ACT), medication usage, forced expiratory volume in one second and forced vital capacity, medical history, comorbidities and 12-month baseline recall data (severe exacerbations (SE) and healthcare utilisation). SE incidence and healthcare utilisation were summarised at 1 and 2 years post-BT. Results: Subjects' baseline characteristics were representative of persons with severe asthma. A comparison of the proportion of subjects experiencing events during the 12 months prior to BT to the 2-year follow-up showed a reduction in SE (90.3% vs 56.1%, p<0.0001), emergency room visits (53.8% vs 25.5%, p<0.0001) and hospitalisations (42.9% vs 23.5 %, p=0.0019). Reductions in asthma maintenance medication dosage were also observed. AQLQ and ACT scores improved from 3.26 and 11.18 at baseline to 4.39 and 15.54 at 2 years, respectively (p<0.0001 for both AQLQ and ACT). Conclusions: The BTGR demonstrates sustained improvement in clinical outcomes and reduction in asthma medication usage 2 years after BT in a real-world population. This is consistent with results from other BT randomised controlled trials and registries and further supports improvement in asthma control after BT.; This study was sponsored by Boston Scientific Corporation, Marlborough, MA, USA. 2022-03-01T11:40:20Z https://hdl.handle.net/11351/11198 Intensive rehabilitation programme for patients with subacute stroke in an inpatient rehabilitation facility: describing a protocol of a prospective cohort study Messaggi Sartor, Monique; Grau-Sánchez, Jennifer; Guillén-Solà, Anna; Boza, Roser; Puig, Josep; Stinear, Cathy; Morgado-Pérez, Andrea; DUARTE, ESTHER Accident cerebrovascular; Rehabilitació; Estudi prospectiu; Accidente cerebrovascular; Rehabilitación; Estudio prospectivo; Rehabilitation; Stroke; Prospective Studies; Rehabilitation is recognised as a cornerstone of multidisciplinary stroke care. Intensity of therapy is related to functional recovery although there is high variability on the amount of time and techniques applied in therapy sessions. There is a need to better describe stroke rehabilitation protocols to develop a better understanding of current practice increasing the internal validity and generalisation of clinical trial results. The aim of this study is to describe an intensive rehabilitation programme for patients with stroke in an inpatient rehabilitation facility, measuring the amount and type of therapies (physical, occupational and speech therapy) provided and reporting functional outcomes. Methods and analysis: This will be a prospective observational cohort study of patients with subacute stroke admitted to our inpatient rehabilitation facility during 2 years. A therapy recording tool was developed in order to describe the rehabilitation interventions performed in our unit. This tool was designed using the Delphi method, literature search and collaboration with senior clinicians. Therapists will record the time spent on different activities available in our unit during specific therapy sessions. Afterwards, the total time spent in each activity, and the total rehabilitation time for all activities, will be averaged for all patients. Outcome variables were divided into three different domains: body structure and function outcomes, activity outcomes and participation outcomes and will be assessed at baseline (admission at the rehabilitation unit), at discharge from the rehabilitation unit and at 3 and 6 months after stroke. Ethics and dissemination: This study was approved by the Medical Research Committee at Hospital del Mar Research Institute (Project ID: 34/C/2017). The results of this study will be presented at national and international congress and submitted for publication in peer-reviewed journals.; This Project is funded by Fundació La Marató TV3 2024-03-15T10:02:51Z https://hdl.handle.net/11351/6871 Impact of COVID-19 Lockdown in Eating Disorders: A Multicentre Collaborative International Study Baenas Soto, Isabel María; Etxandi, Mikel; Munguía, Lucero; Mestre-Bach, Gemma; Sánchez, Isabel; Granero, Roser; Fernández-Real, Jose Manuel Trastorns de l'alimentació; Impacte psicològic; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Confinament; Trastornos de la alimentación; Impacto psicológico; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Confinamiento; Eating Disorders; Psychological impact; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Confinement; Background: The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. Aims: (1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography. Methods: The sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES). Results: Patients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient. Conclusions: The psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients. 2022-01-24T12:43:31Z