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Title:
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Plant Cells as Pharmaceutical Factories
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Author:
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Rischer, Heiko; Häkkinen, Suvi T.; Ritala, Anneli; Seppänen-Laakso, Tuulikki; Miralpeix i Anglada, Bruna; Capell Capell, Teresa; Christou, Paul; Oksman-Caldentey, Kirsi-Marja
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Notes:
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Molecules derived from plants make up a sizeable proportion of the drugs currently available on the market. These include a
number of secondary metabolite compounds the monetary value of which is very high. New pharmaceuticals often originate in nature.
Approximately 50% of new drug entities against cancer or microbial infections are derived from plants or micro-organisms. However,
these compounds are structurally often too complex to be economically manufactured by chemical synthesis, and frequently isolation
from naturally grown or cultivated plants is not a sustainable option. Therefore the biotechnological production of high-value plant secondary
metabolites in cultivated cells is potentially an attractive alternative. Compared to microbial systems eukaryotic organisms such as
plants are far more complex, and our understanding of the metabolic pathways in plants and their regulation at the systems level has been
rather poor until recently. However, metabolic engineering including advanced multigene transformation techniques and state-of-art metabolomics
platforms has given us entirely new tools to exploit plants as Green Factories. Single step engineering may be successful on
occasion but in complex pathways, intermediate gene interventions most often do not affect the end product accumulation. In this review
we discuss recent developments towards elucidation of complex plant biosynthetic pathways and the production of a number of highvalue
pharmaceuticals including paclitaxel, tropane, morphine and terpenoid indole alkaloids in plants and cell cultures.
VTT and UdL gratefully acknowledge support from European Union Framework 7 Program Integrated Project 222716 SmartCell; European Union Framework 7 European Research Council IDEAS Advanced Grant (to PC) Program-BIOFORCE; COST Actions FA0804 Molecular farming: plants as a production platform for high value proteins and FA1006 Plant Metabolic Engineering for High Value Products. |
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Subject(s):
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-Plant cell culture
-Medicinal plants
-Natural products
-Plantes medicinals
-Productes naturals
-Genètica vegetal
-Enginyeria genètica |
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Rights:
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(c) Bentham Science Publishers, 2013
info:eu-repo/semantics/restrictedAccess |
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Document type:
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article
publishedVersion |
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Published by:
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Bentham Science Publishers
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