Title:
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Influenza vaccine coverage, influenza-associated morbidity and all-cause mortality in Catalonia (Spain)
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Author:
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Muñoz Gracia, María del Pilar; Soldevila, Nuria; Martínez, Anna; Carmona, Glòria; Batalla, Joan; Acosta Argueta, Lesly María; Domínguez, Àngela
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Other authors:
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Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa; Universitat Politècnica de Catalunya. LIAM - Laboratori de Modelització i Anàlisi de la Informació |
Abstract:
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The objective of this work was to study the behaviour of influenza with respect to morbidity and allcause
mortality in Catalonia, and their association with influenza vaccination coverage. The study was
carried out over 13 influenza seasons, from epidemiological week 40 of 1994 to week 20 of 2007, and
included confirmed cases of influenza and all-cause mortality. Two generalized linear models were fitted:
influenza-associated morbidity was modelled by Poisson regression and all-cause mortality by negative
binomial regression. The seasonal component was modelled with the periodic function formed by the
sum of the sinus and cosines. Expected influenza mortality during periods of influenza virus circulation
was estimated by Poisson regression and its confidence intervals using the Bootstrap approach. Vaccination
coverage was associated with a reduction in influenza-associated morbidity (p < 0.001), but not with
a reduction in all-cause mortality (p = 0.149). In the case of influenza-associated morbidity, an increase
of 5% in vaccination coverage represented a reduction of 3% in the incidence rate of influenza. There
was a positive association between influenza-associated morbidity and all-cause mortality. Excess mortality
attributable to influenza epidemics was estimated as 34.4 (95% CI: 28.4–40.8) weekly deaths. In
conclusion, all-cause mortality is a good indicator of influenza surveillance and vaccination coverage is
associated with a reduction in influenza-associated morbidity but not with all-cause mortality. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària -Sampling (Statistics) -Mostreig (Estadística) -62D05 Teoria del mostreig, enquestes de mostreig |
Rights:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type:
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Article - Published version Article |
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