Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.

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Title:	Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.
Author:	Rodríguez García, Marta; Climent, Núria; Oliva, Harold; Casanova Güell, Víctor; Franco Fernández, Rafael; Leon, Agathe; Gatell, José M.; García, Felipe; Gallart, Teresa
Other authors:	Universitat de Barcelona
Abstract:	Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce α-defensins1-3 and that α-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of α-defensins1-3 production by DC on disease progression.
Subject(s):	-VIH (Virus) -Immunologia -HIV (Viruses) -Immunology
Rights:	cc-by (c) Rodríguez García, M. et al., 2010 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Public Library of Science (PLoS)
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