On-chip magneto-immunoassay for Alzheimer's biomarker electrochemical detection by using quantum dots as labels

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dc.contributor.author	Medina Sánchez, Mariana
dc.contributor.author	Miserere, Sandrine
dc.contributor.author	Morales Narváez, Eden
dc.contributor.author	Merkoçi, Arben
dc.date	2014-04-15
dc.identifier.citation	Medina, M. [et al.]. On-chip magneto-immunoassay for Alzheimer's biomarker electrochemical detection by using quantum dots as labels. "Biosensors and bioelectronics", 15 Abril 2014, vol. 54, núm. 1, p. 279-284.
dc.identifier.citation	0956-5663
dc.identifier.citation	10.1016/j.bios.2013.10.069
dc.identifier.uri	http://hdl.handle.net/2117/22686
dc.language.iso	eng
dc.relation	http://www.sciencedirect.com/science/article/pii/S0956566313007719
dc.relation	info:eu-repo/grantAgreement/EC/FP7/246513/EU/Nanosystems for the early Diagnosis of Neurodegenerative diseases/NADINE
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria electrònica
dc.subject	Electrochemistry
dc.subject	Biochemical markers
dc.subject	Alzheimer's disease
dc.subject	Alzheimer biomarker
dc.subject	Apolipoprotein E (ApoE)
dc.subject	Electrochemistry
dc.subject	Magnetic beads
dc.subject	Microfluidic
dc.subject	Quantum dots
dc.subject	Electroquímica
dc.subject	Alzheimer, Malaltia d'
dc.title	On-chip magneto-immunoassay for Alzheimer's biomarker electrochemical detection by using quantum dots as labels
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Electrochemical detection of cadmium-selenide/zinc-sulfide (CdSe@ZnS) quantum dots (QDs) as labeling carriers in an assay for apolipoprotein E (ApoE) detection has been evaluated. The immunocomplex was performed by using tosylactivated magnetic beads as preconcentration platform into a flexible hybrid polydimethylsiloxane (PDMS)-polycarbonate (PC) microfluidic chip with integrated screen printed electrodes (SPE). All the immunoassay was performed in chip and in flow mode. The sensitive electrochemical detection was obtained by square wave anodic stripping voltammetry. ApoE was evaluated for its potential as biomarker for Alzheimer's disease detection, achieving a limit of detection (LOD) of ~12.5ngmL-1 with a linear range from 10 to 200ngmL-1 and high accuracy for diluted human plasma. © 2013 Elsevier B.V.
dc.description.abstract	Peer Reviewed

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