Títol:
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No Differences of Immune Activation and Microbial Translocation
Among HIV-infected Children Receiving Combined Antiretroviral
Therapy or Protease Inhibitor Monotherapy
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Autor/a:
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Falcon Neyra, Lola; Benmarzouk-Hidalgo, Omar J.; Madrid, Lola; Noguera Julian, Antoni; Fortuny Guasch, Claudia; Neth, Olaf; López Cortés, Luis F.
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Abstract:
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This is a cross-sectional study of 15 aviremic chronic
HIV-infected children revealing no differences in immune
activation (IA; HLA-DRCD38 CD4 and CD8 T cells, and sCD14) and
microbial translocation (MT; lipopolysaccharides (LPS) and 16S
rDNA) among HIV-infected patients under combined antiretroviral
treatment (cART; n = 10) or ritonavir-boosted protease inhibitor
monotherapy (mtPI/rtv; n = 5). In both cases, IA and MT were
lower in healthy control children (n = 32). This observational
study suggests that ritonavir boosted protease inhibitor
monotherapy (mtPI/rtv) is not associated with an increased state
of IA or MT as compared with children receiving cART. |
Matèries:
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-Infants -Infeccions per VIH -Estudi de casos -Antiretrovirals -Children -HIV infections -Case studies -Antiretroviral agents |
Drets:
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(c) Wolters Kluwer Health, Inc., 2015
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Tipus de document:
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Article Article - Versió publicada |
Publicat per:
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Wolters Kluwer Health, Inc.
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Compartir:
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