To access the full text documents, please follow this link: http://hdl.handle.net/2445/104522

Title:	Birth weight and adult IQ, but not anxious-depressive psychopathology, are associated with cortical surface area: a study in twins.
Author:	Córdova Palomera, Aldo; Fatjó-Vilas Mestre, Mar; Falcón Falcón, Carles Maria; Bargalló Alabart, Núria​; Alemany Sierra, Silvia; Crespo-Facorro, Benedicto; Nenadic, Igor; Fañanás Saura, Lourdes
Other authors:	Universitat de Barcelona
Abstract:	Background Previous research suggests that low birth weight (BW) induces reduced brain cortical sur- face area (SA) which would persist until at least early adulthood. Moreover, low BW has been linked to psychiatric disorders such as depression and psychological distress, and to altered neurocognitive profiles. Aims We present novel findings obtained by analysing high-resolution structural MRI scans of 48 twins; specifically, we aimed: i) to test the BW-SA association in a middle-aged adult sam- ple; and ii) to assess whether either depression/anxiety disorders or intellectual quotient (IQ) influence the BW-SA link, using a monozygotic (MZ) twin design to separate environ- mental and genetic effects. Results Both lower BW and decreased IQ were associated with smaller total and regional cortical SA in adulthood. Within a twin pair, lower BW was related to smaller total cortical and regional SA. In contrast, MZ twin differences in SA were not related to differences in either IQ or depression/anxiety disorders.
Subject(s):	-Bessons -Ansietat -Naixement -Escorça cerebral -Twins -Anxiety -Childbirth -Cerebral cortex
Rights:	cc-by (c) Córdova Palomera et al., 2015 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Public Library of Science (PLoS)
Share:

Show full item record