Title:
|
Cooperative effects between arginine and glutamic acid in the amino acid catalyzed aldol reaction
|
Author:
|
Valero González, Guillem; Moyano i Baldoire, Albert
|
Other authors:
|
Universitat de Barcelona |
Abstract:
|
Catalysis of the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde by mixtures of L-Arg and of L-Glu in wet DMSO takes place with higher enantioselectivity (up to a seven-fold enhancement in the anti- aldol for the 1:1 mixture) than that observed when either L-Glu or L-Arg alone are used as the catalysts. These results can be explained by the formation of a catalytically active hydrogen-bonded complex between both amino acids, and demonstrate the possibility of positive cooperative effects in catalysis by two different α-amino acids. Chirality |
Subject(s):
|
-Aminoàcids -Catàlisi -Química supramolecular -Àcid glutàmic -Quiralitat -Amino acids -Catalysis -Supramolecular chemistry -Glutamic acid -Chirality |
Rights:
|
(c) Wiley, 2016
|
Document type:
|
Article Article - Accepted version |
Published by:
|
Wiley
|
Share:
|
|