Title:
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Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network
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Author:
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Capasso, Serena; Sticco, Lucia; Rizzo, Riccardo; Pirozzi, Marinella; Russo, Domenico; Dathan, Nina A.; Campelo, Felix; Galen, Josse van; Hölttä-Vuori, Maarit; Turacchio, Gabriele; Hausser, Angelika; Malhotra, Vivek; Riezman, Isabelle; Riezman, Howard; Ikonen, Elina; Luberto, Chiara; Parashuraman, Seetharaman; Luini, Alberto; Angelo, Giovanni D
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Other authors:
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Universitat Politècnica de Catalunya. Institut de Ciències Fotòniques |
Abstract:
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Sphingolipids are membrane lipids, which are globally required for eukaryotic life.
Sphingolipid composition varies among endomembranes with pre- and post-Golgi
compartments being poor and rich in sphingolipids, respectively. Thanks to this different
sphingolipid content, pre- and post-Golgi membranes serve different cellular functions.
Nevertheless, how subcellular sphingolipid levels are maintained in spite of trafficking and
metabolic fluxes is only partially understood. Here we describe a homeostatic control
circuit that controls sphingolipid levels at the trans Golgi network. Specifically, we show
that sphingomyelin production at the trans Golgi network triggers a signalling reaction
leading to PtdIns(4)P dephosphorylation. Since PtdIns(4)P is required for cholesterol, and
sphingolipid transport to the trans Golgi network, PtdIns(4)P consumption leads to the
interruption of this transport in response to excessive sphingomyelin production. Based on
this evidence we envisage a model where this homeostatic circuit maintains the lipid
composition of trans Golgi network and thus of post-Golgi compartments constant, against
instant fluctuations in the sphingolipid biosynthetic flow. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Física -Metabolism -Golgi network -Metabolisme |
Rights:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type:
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Article - Submitted version Article |
Published by:
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Embo press
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