Título:
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The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study
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Autor/a:
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Gómez Acebo, Inés; Dierssen Sotos, Trinidad; Palazuelos-Calderón, Camilo; Pérez Gómez, Beatriz; Lope, Virginia; Tusquets, Ignasi; Alonso Aguado, Maria Henar; Moreno Aguado, Víctor; Amiano, Pilar; Molina de la Torre, Antonio José; Barricarte, Aurelio; Tardón, Adonina; Camacho, Antonio; Peiró Pérez, Rosana; Marcos Gragera, Rafael; Muñoz, Montse; Michelena-Echeveste, Maria Jesus; Ortega Valin, Luis; Guevara, Marcela; Castaño-Vinyals, Gemma; Aragonès Sanz, Núria; Kogevinas, Manolis; Pollán, Marina; Llorca Díaz, Javier
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Otros autores:
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Universitat de Barcelona |
Abstract:
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INTRODUCTION: The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers. METHODS: In this case-control study, we report the antihypertensive drugs-breast cancer relationship in 1,736 breast cancer cases and 1,895 healthy controls; results are reported stratifying by the women's characteristics (i.e., menopausal status or body mass index category) tumor characteristics and length of use of antihypertensive drugs. RESULTS: The relationship among breast cancer and use of calcium channel blockers (CCB) for 5 or more years had odds ratio (OR) = 1.77 (95% CI, 0.99 to 3.17). Stratifying by BMI, the OR increased significantly in the group with BMI ≥ 25 (OR 2.54, 95% CI, 1.24 to 5.22). CCBs were even more strongly associated with more aggressive tumors, (OR for invasive tumors = 1.96, 95% CI = 1.09 to 3.53; OR for non ductal cancers = 3.97, 95% CI = 1.73 to 9.05; OR for Erbb2+ cancer = 2.97, 95% CI: 1.20 to 7.32). On the other hand, premenopausal women were the only group in which angiotensin II receptor blockers may be associated with breast cancer (OR = 4.27, 95% CI = 1.32 to 13.84) but this could not be identified with any type or stage. Use of angiotensin-converting-enzyme inhibitors, beta blockers and diuretics were not associated with risk. CONCLUSIONS: In this large population-based study we found that long term use of calcium channel blockers is associated with some subtypes of breast cancer (and with breast cancer in overweight women). |
Materia(s):
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-Càncer de mama -Hormones -Hormonoteràpia -Oncologia -Canals de calci -Breast cancer -Hormones -Hormone therapy -Oncology -Calcium channels |
Derechos:
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cc-by (c) Gómez-Acebo, Ines et al., 2016
http://creativecommons.org/licenses/by/3.0/es |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Public Library of Science (PLoS)
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