Título:
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Maternal HIV infection is an important health determinant in
non-HIV-infected infants
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Autor/a:
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Rupérez, María; González, Raquel; Maculuve, Sónia Amós; Quintó, Llorenç; López Varela, Elisa; Augusto, Orvalho; Vala, Anifa; Nhacolo, Arsénio; Sevene, Esperança Júlia Pires; Naniche, Denise; Menéndez, Clara
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Abstract:
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OBJECTIVE: To assess morbidity and mortality in HIV-exposed
uninfected (HEU) children to help guiding appropriate clinical
care and effective preventive interventions. DESIGN: This is a
longitudinal study comparing two cohorts of children; one born
to HIV-infected women and the other born to HIV-uninfected
women. METHODS: We have analyzed prospectively obtained
information on nutritional status, morbidity and mortality from
966 HEU and 909 HIV-unexposed infants followed up until their
first 18 months of life at a referral health facility in
southern Mozambique. Determinants for adverse health outcomes in
HEU children were also assessed using multivariate logistic
regression. RESULTS: Increased incidence of hospital admissions
(P = 0.0015), shorter survival in the first 18 months of life (P
= 0.0510) and moderate and severe malnutrition (P = 0.0006 and
0.0014, respectively) were observed among HEU children compared
with HIV-unexposed children. Incidence of outpatient attendance
in HEU children was associated with being men, older age and the
mother being on antiretroviral treatment. Among HEU children,
those who were never breastfed, or who were weaned or were
partially breastfed, had an increased incidence of hospital
admissions compared with children who were exclusively
breastfed. CONCLUSION: Maternal HIV infection has important
health consequences in non-HIV-infected children. As the
prevalence of HIV-infected pregnant women is maintained and the
proportion of HIV-infected children declines because of the
scale-up of antiretroviral treatment during pregnancy and
breastfeeding, more focus should be given to the health needs of
HEU children to ensure that the post-2015 sustainable
development goals are met. |
Materia(s):
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-VIH (Virus) -Neonatologia -Mortalitat infantil -Morbiditat -HIV (Viruses) -Neonatology -Infant mortality -Morbidity |
Derechos:
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(c) Current Science, 2017
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Current Science
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Compartir:
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