Title:
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Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials
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Author:
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Bassegoda Puigdomenech, Arnau; Ivanova, Kristina Dimitrova; Ramon Portés, Eva; Tzanov, Tzanko
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Other authors:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial |
Abstract:
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This is a post-peer-review, pre-copyedit version of an article published in Applied microbiology and biotechnology The final authenticated version is available online at: http://dx.doi.org/10.1007/s00253-018-8776-0 |
Abstract:
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Drug resistance occurrence is a global healthcare concern responsible for the increased morbidity and mortality in hospitals, time of hospitalisation and huge financial loss. The failure of the most antibiotics to kill Bsuperbugs^ poses the urgent need to develop innovative strategies aimed at not only controlling bacterial infection but also the spread of resistance. The prevention of pathogen host invasion by inhibiting bacterial virulence and biofilm formation, and the utilisation of bactericidal agents with different mode of action than classic antibiotics are the two most promising new alternative strategies to overcome antibiotic resistance. Based on these novel approaches, researchers are developing different advanced materials (nanoparticles, hydrogels and surface coatings) with novel antimicrobial properties. In this review, we summarise the recent advances in terms of engineered materials to prevent bacteria-resistant infections according to the antimicrobial strategies underlying their design. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Enginyeria química -Antibiotics--Biotechnology -Tissue engineering -Nanoparticles--therapeutic use -Antibiotic resistance -antibiofouling -antimicrobial peptides -quorum sensing -virulence factors -nano-antimicrobial materials -Antibiòtics -- Biotecnologia -Nanopartícules -- Ús terapèutic -Enginyeria de teixits |
Rights:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type:
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Article - Submitted version Article |
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