Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine

Inicio | ¿Qué es? | Contacto

English | Català

Consultar RECERCAT

Por comunidades y
colecciones Por fecha Por autores Por títulos Por temas (CDU)

Consultar departamento

Por fecha Por autores Por títulos Por temas (CDU)

Estadisticas

Del documento Todo RECERCAT

Mi RECERCAT

Entrar Alertas por correo-e

Directorio de otros repositorios

RECERCAT Principal > Universitat de Barcelona > Bioquímica i Biomedicina Molecular > Articles publicats en revistes (Bioquímica i Biomedicina Molecular) > Visualizar documento

Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/122634

dc.contributor	Universitat de Barcelona
dc.contributor.author	Navarro Brugal, Gemma
dc.contributor.author	Quiroz, César
dc.contributor.author	Moreno-Delgado, David
dc.contributor.author	Sierakowiak, Adam
dc.contributor.author	McDowell, Kimberly
dc.contributor.author	Moreno Guillén, Estefanía
dc.contributor.author	Rea, William
dc.contributor.author	Cai, Ning-Sheng
dc.contributor.author	Aguinaga Andrés, David
dc.contributor.author	Howell, Lesley A.
dc.contributor.author	Hausch, Felix
dc.contributor.author	Cortés Tejedor, Antonio
dc.contributor.author	Mallol Montero, Josefa
dc.contributor.author	Casadó, Vicent
dc.contributor.author	Lluís i Biset, Carme
dc.contributor.author	Canela Campos, Enric I.
dc.contributor.author	Ferré, Sergi
dc.contributor.author	McCormick, Peter J.
dc.date	2018-05-29T11:40:04Z
dc.date	2018-05-29T11:40:04Z
dc.date	2015-04-29
dc.date	2018-05-29T11:40:04Z
dc.identifier.citation	0270-6474
dc.identifier.citation	652895
dc.identifier.uri	http://hdl.handle.net/2445/122634
dc.format	15 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	The Society for Neuroscience
dc.relation	Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.4364-14.2015
dc.relation	Journal of Neuroscience, 2015, vol. 35, num. 17, p. 6639-6653
dc.relation	https://doi.org/10.1523/JNEUROSCI.4364-14.2015
dc.rights	cc-by-nc-sa (c) Navarro Brugal, Gemma et al., 2015
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-sa/3.0/es
dc.subject	Receptors cel·lulars
dc.subject	Cocaïna
dc.subject	Cell receptors
dc.subject	Cocaine
dc.title	Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior. We provide evidence for pharmacologically significant interactions between CRF and orexin-A that depend on oligomerization of CRF1 receptor (CRF1R) and orexin OX1 receptors (OX1R). CRF1R-OX1R heteromers are the conduits of a negative crosstalk between orexin-A and CRF as demonstrated in transfected cells and rat VTA, in which they significantly modulate dendritic dopamine release. The cocaine target sigma1 receptor (sigma1R) also associates with the CRF1R-OX1R heteromer. Cocaine binding to the sigma1R-CRF1R-OX1R complex promotes a long-term disruption of the orexin-A-CRF negative crosstalk. Through this mechanism, cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces cocaine seeking.

Mostrar el registro sencillo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine

Navarro Brugal, Gemma; Quiroz, César; Moreno-Delgado, David; Sierakowiak, Adam; McDowell, Kimberly; Moreno Guillén, Estefanía; Rea, William; Cai, Ning-Sheng; Aguinaga Andrés, David; Howell, Lesley A.; Hausch, Felix; Cortés Tejedor, Antonio; Mallol Montero, Josefa; Casadó, Vicent; Lluís i Biset, Carme; Canela Campos, Enric I.; Ferré, Sergi; McCormick, Peter J.

Functional μ-opioid-galanin receptor heteromers in the ventral tegmental area

Moreno Guillén, Estefanía; Quiroz, César; Rea, William; Cai, Ning-Sheng; Mallol Montero, Josefa; Cortés Tejedor, Antonio; Lluís i Biset, Carme; Canela Campos, Enric I.; Casadó, Vicent; Ferré, Sergi

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects

Moreno Guillén, Estefanía; Moreno-Delgado, David; Navarro Brugal, Gemma; Hoffmann, Hanne; Fuentes, Silvia; Rosell-Vilar, Santi; Gasperini, Paola; Rodríguez-Ruiz, Mar; Medrano, Mireia; Mallol Montero, Josefa; Cortés Tejedor, Antonio; Casadó, Vicent; Lluís i Biset, Carme; Ferré, Sergi; Ortiz, Jordi; Canela Campos, Enric I.; McCormick, Peter J.

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain

Navarro Brugal, Gemma; Cordomí, Arnau; Brugarolas Campillos, Marc; Moreno Guillén, Estefanía; Aguinaga Andrés, David; Pérez-Benito, Laura; Ferré, Sergi; Cortés Tejedor, Antonio; Casadó, Vicent; Mallol Montero, Josefa; Canela Campos, Enric I.; Lluís i Biset, Carme; Pardo, Leonardo; McCormick, Peter J.; Franco Fernández, Rafael

Accesibilidad | Aviso legal | Política de Cookies | Documentos de uso interno

Coordinación

Patrocinio