To access the full text documents, please follow this link: http://hdl.handle.net/10230/33093
Title: | In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities |
---|---|
Author: | Rubio Pérez, Carlota, 1990-; Tamborero Noguera, David; Schroeder, Michael Philipp, 1986-; Antolín Hernández, Albert, 1984-; Déu Pons, Jordi; Pérez Llamas, Christian, 1976-; Mestres i López, Jordi; González-Pérez, Abel; López Bigas, Núria |
Abstract: | Large efforts dedicated to detect somatic alterations across tumor genomes/exomes are expected to produce significant improvements in precision cancer medicine. However, high inter-tumor heterogeneity is a major obstacle to developing and applying therapeutic targeted agents to treat most cancer patients. Here, we offer a comprehensive assessment of the scope of targeted therapeutic agents in a large pan-cancer cohort. We developed an in silico prescription strategy based on identification of the driver alterations in each tumor and their druggability options. Although relatively few tumors are tractable by approved agents following clinical guidelines (5.9%), up to 40.2% could benefit from different repurposing options, and up to 73.3% considering treatments currently under clinical investigation. We also identified 80 therapeutically targetable cancer genes. |
Abstract: | We acknowledge funding from the Spanish Ministry of Economy and Competitiveness (grant number SAF2012-36199), La Fundació la Marató de TV3, and the Spanish National Institute of Bioinformatics (INB). C.R.-P. and M.P.S. are supported by an FPI fellowship. D.T. is supported by the People Programme (Marie Curie Actions) of the Seventh Framework Programme of the European Union (FP7/2007-2013) under REA grant agreement number 600388 and by the Agency of Competitiveness for Companies of the Government of Catalonia, ACCIÓ. A.G.-P. is supported by a Ramón y Cajal contract. |
Subject(s): | -Antineoplastic Agents -Carcinogenesis/genetics -Clinical Protocols -Clinical Trials as Topic -Cohort Studies -Computational Biology -DNA Mutational Analysis -Drug Repositioning -Decision Making, Computer-Assisted -Neoplasms/drug therapy -Neoplasms/genetics -Precision Medicine/methods |
Rights: | https://www.elsevier.com/about/our-business/policies/open-access-licenses/elsevier-user-license
© Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.ccell.2015.02.007 that appeared in the journal Cancer Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: https://www.elsevier.com/about/our-business/policies/open-access-licenses/elsevier-user-license |
Document type: | Article Article - Published version |
Published by: | Elsevier |
Share: |