Title:
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Neurodegenerative diseases: quantitative predictions of protein-RNA interactions
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Author:
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Cirillo, Davide; Agostini, Federico, 1985-; Klus, Petr, 1985-; Marchese, Domenica, 1986-; Rodríguez, Silvia; Bolognesi, Benedetta; Tartaglia, Gian Gaetano
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Abstract:
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Increasing evidence indicates that RNA plays an active role in a number of neurodegenerative diseases. We recently introduced a theoretical framework, catRAPID, to predict the binding ability of protein and RNA molecules. Here, we use catRAPID to investigate ribonucleoprotein interactions linked to inherited intellectual disability, amyotrophic lateral sclerosis, Creutzfeuld-Jakob, Alzheimer's, and Parkinson's diseases. We specifically focus on (1) RNA interactions with fragile X mental retardation protein FMRP; (2) protein sequestration caused by CGG repeats; (3) noncoding transcripts regulated by TAR DNA-binding protein 43 TDP-43; (4) autogenous regulation of TDP-43 and FMRP; (5) iron-mediated expression of amyloid precursor protein APP and α-synuclein; (6) interactions between prions and RNA aptamers. Our results are in striking agreement with experimental evidence and provide new insights in processes associated with neuronal function and misfunction. |
Abstract:
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This work was supported by the Spanish Ministry of Economy and Competitiveness (SAF2011-26211), the Programa de Ayudas FPI del Ministerio de Economia y Competitividad—BES-2012-052457 and by a grant from “la Caixa” to Petr Klus |
Subject(s):
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-Algoritmes -Síndrome del cromosoma X fràgil -Sistema nerviós -- Degeneració -RNA -Proteïnes |
Rights:
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This is an Open Access article distributed under the terms of a Creative Commons Attribution License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0/)
http://creativecommons.org/licenses/by-nc/4.0/ |
Document type:
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Article Article - Published version |
Published by:
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Cold Spring Harbor Laboratory Press (CSHL Press)
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