Effect of applied voltage, duration and repetition frequency of RF pulses for pain relief on temperature spikes and electrical field: a computer modeling study

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To access the full text documents, please follow this link: http://hdl.handle.net/10230/30922

dc.contributor.author	Ivorra Cano, Antoni, 1974-
dc.contributor.author	Ewertowska, Elżbieta
dc.contributor.author	Mercadal Cavaller, Borja
dc.contributor.author	Muñoz, Víctor
dc.contributor.author	Trujillo, Macarena
dc.contributor.author	Berjano, Enrique J.
dc.date	2018
dc.identifier.citation	Ewertowska E, Mercadal B, Muñoz V, Ivorra A, Trujillo M, Berjano E. Effect of applied voltage, duration and repetition frequency of RF pulses for pain relief on temperature spikes and electrical field: a computer modeling study. Int J Hyperthermia. 2018;34(1): 112-21. DOI: 10.1080/02656736.2017.1323122
dc.identifier.citation	0265-6736
dc.identifier.citation	http://dx.doi.org/10.1080/02656736.2017.1323122
dc.identifier.uri	http://hdl.handle.net/10230/30922
dc.description.abstract	Background: The thermal and electrical effects of pulsed radiofrequency (PRF) for pain relief can be controlled by modifying the characteristics of the RF pulses applied. Our goal was to evaluate the influence of such modifications on the thermal and electric performance in tissue. Methods: A computational model was developed to compare the temperature and electric field time courses in tissue between a standard clinical protocol (45 V pulses, 20 ms duration, 2 Hz repetition frequency) and a new protocol (55 V pulses, 5 ms duration, 5 Hz repetition frequency) with a higher applied electric field but a smaller impact on temperature alterations in tissue. The effect of including a temperature controller was assessed. Complementarily, an agar-based experimental model was developed to validate the methodology employed in the computer modeling. Results: The new protocol increased the electric field magnitude reached in the tissue by around +20%, without increasing the temperature. The temperature controller was found to be the fundamental factor in avoiding thermal damage to the tissue and reduced the total number of pulses delivered by around 67%. The experimental results matched moderately well with those obtained from a computer model built especially to mimic the experimental conditions. Conclusions: For the same delivered energy, the new protocol significantly increases the magnitude of the applied electric field, which may be the reason why it is clinically more effective in achieving pain relief.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Taylor & Francis (Routledge)
dc.relation	Int J Hyperthermia. 2017. 2018;34(1): 112-21.
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	© Taylor & Francis. This is an electronic version of an article published in [include the complete citation information for the final version of the article as published in the print edition of the journal]. International Journal of Hyperthermia is available online at: http://www.tandfonline.com/doi/abs/10.1080/02656736.2017.1323122
dc.subject	Computational model
dc.subject	Electroporation
dc.subject	Pain relief
dc.subject	Pulsed radiofrequency
dc.subject	Temperature spike
dc.title	Effect of applied voltage, duration and repetition frequency of RF pulses for pain relief on temperature spikes and electrical field: a computer modeling study
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion

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