Autor/a:
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Martí Coma Cros, Elisabet; Biosca, Arnau; Lantero, Elena; Manca, Maria Letizia; Caddeo, Carla; Gutiérrez, Lucía; Ramírez, Miriam; Borgheti Cardoso, Livia Neves; Manconi, Maria; Fernàndez Busquets, Xavier
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Abstract:
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Curcumin is an antimalarial compound easy to obtain and
inexpensive, having shown little toxicity across a diverse
population. However, the clinical use of this interesting
polyphenol has been hampered by its poor oral absorption,
extremely low aqueous solubility and rapid metabolism. In this
study, we have used the anionic copolymer Eudragit(®)
S100 to assemble liposomes incorporating curcumin and containing
either hyaluronan (Eudragit-hyaluronan liposomes) or the
water-soluble dextrin Nutriose(®) FM06
(Eudragit-nutriosomes). Upon oral administration of the
rehydrated freeze-dried nanosystems administered at 25/75 mg
curcumin·kg(−1)·day(−1), only Eudragit-nutriosomes improved the in vivo antimalarial activity of curcumin in a dose-dependent manner, by enhancing the survival of all Plasmodium yoelii-infected mice up to 11/11 days, as compared to 6/7 days upon administration of an equal dose of the free compound. On the other hand, animals treated with curcumin incorporated in Eudragit-hyaluronan liposomes did not live longer than the controls, a result consistent with the lower stability of this formulation after reconstitution. Polymer-lipid nanovesicles hold promise for their development into systems for the oral delivery of curcumin-based antimalarial therapies. |