Título:
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Organocatalytic Enantioselective Continuous Flow Cyclopropanation
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Autor/a:
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Llanes, Patricia; Rodríguez-Escrich, Carles; Sayalero, Sonia; Pericàs, Miquel A.
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Abstract:
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A set of six solid-supported diarylprolinol catalysts (varying on the anchoring strategy and the type of polymeric support) has been prepared and applied to the enantioselective cyclopropanation reaction. The selected candidate allows implementation of a long flow experiment (48 h) and generates a library of 12 cyclopropanes by sequential flow experiments. The mildness and utility of the method have enabled a telescoped process in which the outstream is directly used in a Wittig flow reaction. |
Fecha de creación:
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07-12-2016 |
Materia(s):
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Quimica |
Derechos:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Páginas:
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6292 p. |
Tipo de documento:
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Artículo Artículo - Borrador |
DOI:
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10.1021/acs.orglett.6b03156
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Editor:
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Org. Lett.
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