Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells

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Title:	Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
Author:	Gandioso, Albert; Massaguer i Vall-llovera, Anna; Villegas, Núria; Salvans, Cándida; Sánchez, Dani; Brun-Heath, Isabelle; Marchán Sancho, Vicente; Orozco López, Modesto; Terrazas Martínez, Montserrat
Other authors:	Universitat de Barcelona
Abstract:	Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different size and complexity. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines.
Subject(s):	-RNA -Pèptids -Càncer de mama -Cèl·lules canceroses -RNA -Peptides -Breast cancer -Cancer cells
Rights:	(c) Gandioso et al., 2017
Document type:	Article Article - Accepted version
Published by:	Royal Society of Chemistry
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